The relative intensity of daily life activities in individuals with neuromuscular diseases.

Completed

Conditions: Neuromuscular diseases
NMD
10029317

Registration Number: NL-OMON45961

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

(1) Diagnosed with a Neuromuscular Disease.
(2) Muscle weakness in the upper or lower extremities; e.g. a score of <5 according to the Medical Research Council [MRC] scale in one of the following muscle groups; shoulder flexors and extensors, shoulder ab- and adductors, elbow flexors and extensors, wrist flexors and extensors, hip flexors and extensors, hip abductors and adductors, knee flexors and extensors, and ankle dorsi- and plantarflexors, or signs of fat infiltration during MRI in one of the upper or lower extremity muscle groups.
(3) Minimum age of 18 years.

Exclusion Criteria

(1) Insufficient mastery of the Dutch language.
(2) Cognitive impairment.
(3) Contra-indications for maximal exercise testing according to the guidelines by the American College of Sports Medicine (ACSM).

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>(1) The amount of time spent at low (<40%HRR), moderate (40-60%HRR), and<br /><br>vigorous (>60%HRR) intensities during ADL.<br /><br><br /><br>ADL (active minutes) will be assessed by an ankle worn activity monitor during<br /><br>7 consecutive days. During the same period, the heart rate will be assessed<br /><br>with a heart rate monitor (HRADL, bpm). To determine the relative intensity of<br /><br>ADL, heart rate responses will be expressed relative to the individuals* heart<br /><br>rate reserve (HRR), defined as the difference between resting and peak heart<br /><br>rate (HRpeak, bpm). HRpeak will be measured in a maximal exercise test. </p><br>

Secondary Outcome Measures