Risk Factors and Impact of Anesthesia Techniques on Myocardial Infarction Following Transurethral Resection of the Prostate

Completed

• Conditions: Myocardial Infarction; Anesthesia; Transurethral Resection of Prostate Syndrome

• Registration Number: NCT04047329
• Lead Sponsor: Chang Gung Memorial Hospital

Brief Summary

This study examined the risk factors and the influence of the type of anesthetic used during transurethral resection of the prostate (TURP) on subsequent incidence of myocardial infarction (MI).

Detailed Description

This study utilized a population-based, nationwide dataset to evaluate the risk factors of MI for patients with benign prostate hypertrophy (BPH) who received TURP. Besides, The study also compared the different effects of general anesthesia (GA) and neuraxial anesthesia (NA) on the incidence of MI within 6 and 12 months after TURP.

Study Timeline

• Study Start: 1998-01-01
• Primary Completion: 2012-12-31
• Status Verified: 2015-09
• Study Completion: 2016-03-22
• Study First Submitted: 2019-07-23
• Study First Submitted QC: 2019-08-05
• Last Update Submitted: 2019-08-05
• Study First Posted: 2019-08-06
• Last Update Posted: 2019-08-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 115025

Inclusion Criteria

• Patients receiving TURP surgery (1998-2012)

Exclusion Criteria

• Patients without anesthesia records
• Patients receiving both general and neuraxial anesthesia
• Mortality within 12 months of TURP

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of patients with pre-operative diagnosed hypertension developing post-TURP myocardial infarction	within 12 months after the first admission for TURP	We analyze pre-operative diagnosed hypertension rate in patients who had myocardial infarction after the surgery of TURP.
Patient's age (year-old) that developed post-TURP myocardial infarction	within 12 months after the first admission for TURP	We analyze age distribution of patients with post-TURP myocardial infarction
Number of patients with pre-operative diagnosed heart disease history developing post-TURP myocardial infarction	within 12 months after the first admission for TURP	We analyze pre-operative diagnosed heart disease rate in patients who had myocardial infarction after the surgery of TURP.
Number of patients with pre-operative diagnosed stroke history developing post-TURP myocardial infarction	within 12 months after the first admission for TURP	We analyze pre-operative diagnosed stroke rate in patients who had myocardial infarction after the surgery of TURP.
Postoperative myocardial infarction	within 12 months after the first admission for TURP	Patients experienced myocardial infarction after transurethral resection of the prostate (TURP)
Number of patients with pre-operative diagnosed gout developing post-TURP myocardial infarction	within 12 months after the first admission for TURP	We analyze pre-operative diagnosed gout rate in patients who had myocardial infarction after the surgery of TURP.
Number of patients with pre-operative diagnosed liver cirrhosis history developing post-TURP myocardial infarction	within 12 months after the first admission for TURP	We analyze pre-operative diagnosed liver cirrhosis rate in patients who had myocardial infarction after the surgery of TURP.
Number of patients with pre-operative diagnosed chronic obstructive pulmonary disease developing post-TURP myocardial infarction	within 12 months after the first admission for TURP	We analyze pre-operative diagnosed chronic obstructive pulmonary disease rate in patients who had myocardial infarction after the surgery of TURP.
Number of patients with pre-operative diagnosed Diabetes Mellitus developing post-TURP myocardial infarction	within 12 months after the first admission for TURP	We analyze pre-operative diagnosed Diabetes Mellitus rate in patients who had myocardial infarction after the surgery of TURP.
Number of patients with pre-operative diagnosed disorders of lipoid metabolism developing post-TURP myocardial infarction	within 12 months after the first admission for TURP	We analyze pre-operative diagnosed disorders of lipoid metabolism rate in patients who had myocardial infarction after the surgery of TURP.
Number of patients with pre-operative diagnosed asthma developing post-TURP myocardial infarction	within 12 months after the first admission for TURP	We analyze pre-operative diagnosed asthma rate in patients who had myocardial infarction after the surgery of TURP.

Secondary Outcome Measures

Name	Time	Method
Number of patients who did not have post-operative myocardial infarction after receiving general anesthesia for TURP	within 12 months after the first admission for TURP	Number of patients who did not have post-operative myocardial infarction after receiving general anesthesia for TURP
Number of patients who had post-operative myocardial infarction after receiving general anesthesia for TURP	within 6 months after the first admission for TURP	Number of patients who had post-operative myocardial infarction after receiving general anesthesia for TURP
Number of patients who had post-operative myocardial infarction after receiving neuraxial anesthesia for TURP	within 6 months after the first admission for TURP	Number of patients who had post-operative myocardial infarction after receiving neuraxial anesthesia for TURP
Number of patients who did not have post-operative myocardial infarction after receiving neuraxial anesthesia for TURP	within 12 months after the first admission for TURP	Number of patients who did not have post-operative myocardial infarction after receiving neuraxial anesthesia for TURP