Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain
Overview
- Phase
- Phase 4
- Status
- Completed
- Enrollment
- 10
- Primary Endpoint
- Pain Score, Chronic
Overview
Brief Summary
Research suggests that the type of anesthesia used for surgery may affect intraoperative stress hormone levels. There is also data to support that an increased level of stress hormones leads to increased pain after surgery. The primary aim of this study is to determine the effect of anesthesia type on long term pain after hernia surgery. In this study, patients undergoing inguinal hernia repair will be randomized to an anesthetic group, either Total Intravenous Anesthesia (TIVA) maintained with propofol or Balanced Inhaled Anesthesia (BIA) maintained with sevoflurane. This will allow us to look at any differences in short and long-term pain after hernia repair depending on type of anesthesia received.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •All male patients undergoing herniorrhaphy surgery that requires general anesthesia.
Exclusion Criteria
- •Subjects unable to communicate directly with the investigators, due to being non-English speaking, loss of hearing, or incompetence.
- •A history of malignant hyperthermia, pseudocholinesterase deficiency, or other disease that prevents anesthetic randomization.
- •Pain-related disorders such as fibromyalgia or other chronic pain syndromes.
- •Emergency surgery.
Arms & Interventions
BIA
Balanced Inhalational Anesthesia (consisting of a sevoflurane inhaled anesthestic only)
Intervention: Sevoflurane (Drug)
BIA
Balanced Inhalational Anesthesia (consisting of a sevoflurane inhaled anesthestic only)
Intervention: Remifentanil (Drug)
TIVA-K
Total intravenous anesthetic with ketamine
Intervention: Propofol (Drug)
TIVA-K
Total intravenous anesthetic with ketamine
Intervention: Ketamine (Drug)
TIVA-R
Total intravenous anesthetic with remifentanil
Intervention: Propofol (Drug)
TIVA-R
Total intravenous anesthetic with remifentanil
Intervention: Remifentanil (Drug)
Outcomes
Primary Outcomes
Pain Score, Chronic
Time Frame: 1 month, 3 months, 6 months, 12 months
Pain as measured by the Intensity Score of the Pain Quality Assessment Scale (PQAS) at each of the time points after surgery. The scale goes from 0 (no pain) to 10 (the most intense pain sensation imaginable). Higher scores mean worse pain.
Secondary Outcomes
- Pain Score, Acute(1 day)