The Influence of Anesthetic Technique on Interleukin Plasma Level in Colorectal Cancer Surgery - TIVA vs Inhalation Anesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- measurement of interleukins IL6 and IL10 plasmatic level
研究概览
简要总结
Knowing the fact that the anesthetic substances can alter the immune response during the surgery, the purpose of the study is to evaluate the influence of two general anesthetic techniques - inhalation vs. total intravenous anesthesia on the immune response in patient with colorectal surgery for neoplastic disease, evaluated by the plasma level of the interleukins 6 and 10(IL6, IL10).
详细描述
Introduction
Several factors are contributing to perioperative immunosuppression such as: surgery itself, general anesthesia. In vivo and in vitro studies have shown that anesthesia itself may alter the immune response either by direct effect on immune cells (such as natural killer and T helper) ) or indirectly by the influence of anesthetic substances on pro (IL-1, IL-6, tumor necrosis factor alpha ) and anti-inflammatory ( IL-4, IL-10) cytokines release.
The study aims to evaluate the influence of two general anesthetic techniques inhalation versus total intravenous anesthesia- target controlled infusion (TIVA-TCI) on the immune response in patient with colorectal surgery for neoplastic disease, evaluated by the plasma level of the interleukins IL6, IL10.
Study group:
- patients admitted to the Surgical Clinic of the Regional Institute of Gastroenterology and Hepatology Prof Dr Octavian Fodor, undergoing open surgery for colorectal cancer (right/left colectomy, colorectal resection).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients over 18 years with ASA physical status I-III.
- •colorectal cancer patients with no sign of local invasion (adjacent organs) and distant metastasis revealed by imaging studies
- •surgery performed by the same surgical team
排除标准
- •ASA physical status IV patients
- •hepatic and renal impairment
- •diabetes or other endocrine disorders
- •obesity (BMI 30 kg/m2)
- •immune disorders or immunosuppressive therapy
- •steroid treatment in the last 6 months
结局指标
主要结局
measurement of interleukins IL6 and IL10 plasmatic level
时间窗: 2 hours postoperatively (T2)
measurement of interleukins IL6 and IL 10 plasmatic level
时间窗: 24 hours postoperatively (T3)
measurement of interleukins IL6, IL10 plasmatic level
时间窗: after anesthesia induction but before surgical incision (T1)
* in group I (TIVA-TCI) when plasma concentration of propofol is 3-3.5 micrograms/ml * in group II (ISOFLURANE) when concentration of isoflurane in exhaled gases (Et iso) is between 0.3-0.5 %
次要结局
- total opioid analgesic dose (mg)(for the first 24 hours postoperatively)
研究者
Margarit Simona
senior lecturer, consultant in anesthesia and intensive care
Iuliu Hatieganu University of Medicine and Pharmacy