The Effect of Anesthesia on Systemic Inflammatory Immune Index in Major Abdominal Cancer Surgeries

Completed

• Conditions: Cancer Gi; Cancer of Endometrium; Systemic Immune Activation

• Registration Number: NCT04891146
• Lead Sponsor: Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital

Brief Summary

The effects of different anesthesia methods on the immune system are variable. In this study, we investigated the effect of inhalation anesthesia and total intravenous anesthesia on the SII value in major abdominal cancer surgeries.

Detailed Description

The study was planned prospectively, observationally, on a total of 90 patients who underwent major abdominal cancer surgery. 84 patients were evaluated. The patients were seperated in two groups as inhalation anesthesia and total intravenous anesthesia (TIVA). The demographic data of the patients, type of cancer, type of surgery performed, ASA classification, preoperative chemotherapy intake, preoperative hemogram, postoperative 2nd and 24th hour hemogram, intraoperative and postoperative blood transfusion, and duration of surgery were recorded. Platelet, neutrophil, lymphocyte and SII values were saved.

Study Timeline

• Study Start: 2020-03-05
• Primary Completion: 2020-09-15
• Study Completion: 2020-12-12
• Status Verified: 2021-03
• Study First Submitted: 2021-03-17
• Study First Submitted QC: 2021-05-14
• Last Update Submitted: 2021-05-14
• Study First Posted: 2021-05-18
• Last Update Posted: 2021-05-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 84

Inclusion Criteria

• major abdominal cancer surgeries

Exclusion Criteria

• blood transfusion in last 72 hours
• patients with infection
• hematologic malignancy
• patient controlled analgesia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
investigate the effect of anesthesia management on the change of preoperative systemic inflammatory immune index(SII) and postoperative 2.hour and 24.hour SII value	preoperative SII noted, postoperative 2.hour noted and postoperative 24.hour noted	systemic inflammatory immune index calculated by (platelet x neutrophil)/lymphocyte

Trial Locations

Locations (1)

Dr. Abdurrahman Yurtaslan Oncology Research and Trainee Hospital; 🇹🇷 Ankara, Yenimahalle, Turkey