Oral Immunotherapy for Peanut and Mammalian Meat Allergies
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- The Level of Allergen Consumed Post-oral Immunotherapy
研究概览
简要总结
Pilot study to assess the effect of oral immunotherapy on specific Immunoglobulin E (IgE) levels and antigen consumption in two distinct food allergies.
详细描述
In subjects with mammalian meat allergy, the effect of daily oral cow's milk on immune parameters and desensitization will be assessed. Similarly, in subjects with a peanut allergy the effects of low dose peanut flour will be assessed and comparisons between two distinct food allergies.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 4 Years 至 80 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Presence or absence of specific IgE to alpha-gal or peanut
排除标准
- •History of severe anaphylaxis
- •allergy to cow's milk protein
结局指标
主要结局
The Level of Allergen Consumed Post-oral Immunotherapy
时间窗: Following 36 months of maintenance oral immunotherapy, participants completed an open challenge at month 37
consumption of cow's milk or peanut flour at open challenge. This is a single time-point assessment; not measured repeatedly.
次要结局
未报告次要终点
研究者
Scott Commins, MD
Associate Professor, Department of Medicine, Allergy and Immunology
University of Virginia