Oral Immunotherapy for Peanut and Mammalian Meat Allergies

Not Applicable

Completed

• Conditions: Food Hypersensitivity

• Registration Number: NCT02350660
• Lead Sponsor: University of Virginia

Brief Summary

Pilot study to assess the effect of oral immunotherapy on specific Immunoglobulin E (IgE) levels and antigen consumption in two distinct food allergies.

Detailed Description

In subjects with mammalian meat allergy, the effect of daily oral cow's milk on immune parameters and desensitization will be assessed. Similarly, in subjects with a peanut allergy the effects of low dose peanut flour will be assessed and comparisons between two distinct food allergies.

Study Timeline

• Study Start: 2012-03
• Primary Completion: 2014-09
• Study First Submitted: 2015-01-21
• Study First Submitted QC: 2015-01-27
• Study First Posted: 2015-01-30
• Study Completion: 2015-06
• Results First Submitted: 2016-05-10
• Status Verified: 2020-11
• Results First Submitted QC: 2020-11-02
• Last Update Submitted: 2020-11-02
• Results First Posted: 2020-11-03
• Last Update Posted: 2020-11-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Presence or absence of specific IgE to alpha-gal or peanut

Exclusion Criteria

• History of severe anaphylaxis
• allergy to cow's milk protein

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
The Level of Allergen Consumed Post-oral Immunotherapy	Following 36 months of maintenance oral immunotherapy, participants completed an open challenge at month 37	consumption of cow's milk or peanut flour at open challenge. This is a single time-point assessment; not measured repeatedly.

Trial Locations

Locations (1)

University of Virginia; 🇺🇸 Charlottesville, Virginia, United States