Oral Immunotherapy for Peanut and Mammalian Meat Allergies
Not Applicable
Completed
- Conditions
- Food Hypersensitivity
- Interventions
- Dietary Supplement: peanut powderDietary Supplement: cow's milk
- Registration Number
- NCT02350660
- Lead Sponsor
- University of Virginia
- Brief Summary
Pilot study to assess the effect of oral immunotherapy on specific Immunoglobulin E (IgE) levels and antigen consumption in two distinct food allergies.
- Detailed Description
In subjects with mammalian meat allergy, the effect of daily oral cow's milk on immune parameters and desensitization will be assessed. Similarly, in subjects with a peanut allergy the effects of low dose peanut flour will be assessed and comparisons between two distinct food allergies.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 24
Inclusion Criteria
- Presence or absence of specific IgE to alpha-gal or peanut
Exclusion Criteria
- History of severe anaphylaxis
- allergy to cow's milk protein
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Peanut powder peanut powder peanut oral immunotherapy Cow's milk for alpha-gal allergics cow's milk daily consumption of cow's milk
- Primary Outcome Measures
Name Time Method The Level of Allergen Consumed Post-oral Immunotherapy Following 36 months of maintenance oral immunotherapy, participants completed an open challenge at month 37 consumption of cow's milk or peanut flour at open challenge. This is a single time-point assessment; not measured repeatedly.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Virginia
🇺🇸Charlottesville, Virginia, United States