Pilot study, effectiveness of 0.1% alcohol-free chitosan-curcumin mouthwash in the treatment of oral lichen planus and prevention of its recurrence: a single-blinded randomized control trial

Phase 1

Recruiting

• Conditions: oral lichen planus superinfection oral candidiasis atrophy; oral lichen planus; curcumin; triamcinolone

• Registration Number: TCTR20200910005
• Lead Sponsor: Faculty of Pharmacy, Princ of Sonkla University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-09-10
• Study Completion: 2020-12-27
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

Volunteers who were diagnosed of oral lichen planus
1.18 year old or over
2.ability to use mouthwash by ourself
3.be able to read thia lanquague
4.do not use other drug for treatment of oral lichen planus during study

Exclusion Criteria

1.volunteers who were diagnosed of other lesions
2.taking oral route of curcumin
3.contraindication for corticosteroids, curcumin, or chitosan
4.were treatment of lichen planus within 1 month
5.no. of C. albicans is over 400 CFU/ml or oral candidiasis
6.stomatitis from other causes eg. trauma, recurrent apthous ulcer, HIV, other infectious lesions, and lichenoid reaction
7.use other mouthwash within 1 month eg. antiseptic mouthwash, analgesic drug
8.chemotherapy, radiotherapy, or immunosppressive drug within 1 monthา
9.Challacombe oral druness scale more than 4 point

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
severity and pain of lesions 4 weeks numerical scale

Secondary Outcome Measures

Name	Time	Method
satifactory of mouthwash 4 weeks numerical scale,duration of remission stage 6 months time period