Positron Emission Tomography (PET) scan in predicting response and survival in patients undergoing chemoradiation followed by surgery for oesophageal cancer

Phase 2

Active, not recruiting

• Conditions: oesophageal carcinoma; Cancer - Oesophageal (gullet)

• Registration Number: ACTRN12614000676617
• Lead Sponsor: Dr Ariyanto Pramana

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-06-26
• Last Update Posted: 16 October 2022

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 69

Inclusion Criteria

Age greater than or equal to 18 years

Surgically resectable carcinoma of oesophagus (PET staged T1-3, N0-1, M0)

No invasion of the tracheobronchial tree

Tumour must not extend greater than 2cm into the stomach

ECOG between 0 and 2

Patients must have adequate haematological, renal, hepatic, and pulmonary functions defined as: granulocytes greater than or equal to 1.5 x 10^9/L, platelets greater than or equal to 100 x 10^9/L, total bilirubin less than or equal to 1.5 x upper normal limit, and creatinine clearance greater than or equal to 50ml/min

Non-English speaking background patient is allowed as long as interpreter service is provided during the enrolment, treatment, and follow up phase

Exclusion Criteria

Past or current history of malignancy other than entry diagnosis
-History of another malignancy within 5 years prior to registration. Participants with curatively treated cervical carcinoma in situ, non-melanomatous carcinoma of the skin, or superficial bladder tumours (T1a[Non-invasive tumour], and Tis[Carcinoma in situ]), or participants who have been free of other malignancies for greater than or equal to 5 years prior to enrolment are eligible for this study

Previous chemotherapy or radiotherapy

Myocardial infarct in last 6 months

Congestive heart failure or uncontrolled arrhythmia

Neurotoxicity grade greater than 1

Uncontrolled diabetes mellitus despite maximum therapy

Pregnancy, lactation or inadequate contraception

Known allergic reaction to FDG PET contrast

Study & Design

• Study Type: Interventional
• Study Design: Not specified