Effects of dietary Centella asiatica extract on cognition and oxidative stress markers in elderly with mild cognitive impairment

Not Applicable

Completed

• Conditions: Mild Cognitive Impairment (MCI) is commonly being used to refer a stage of cognitive impairment prior to attaining clinical dementia in Alzheimer disease. The plant Centella asiatica (L) Urban is used; dementia, aging, Centella asiatica, cognition, oxidative stress

• Registration Number: TCTR20180228001
• Lead Sponsor: Kasetsart University Research and Development Institute

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2017-09-30
• Study Start: 2018-02-28
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Men and women were aged 65 yrs and above.
They obtained a Mini-Mental State Examination (MMSE) score of ≤23.

Exclusion Criteria

Presentation cardiovascular and/or cerebrovascular disease, uncontrolled hypertension and diabetes, liver and kidney function
impairment, or the presence of other medical conditions with significant psychiatric or neurologic consequence.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cognitive function at 8 weeks after end of the intervention Mini-Mental State Examination (MMSE), reaction time

Secondary Outcome Measures

Name	Time	Method
Oxidatives stress at 8 weeks after end of the intervention Acetylcholinesterase Competitive Enzyme Immunoassay Kit,Vitamin E at 8 weeks after end of the intervention high performance liquid chromatography (HPLC)