FUNCTIONAL GENOMIC RESEARCH IN OSTEOARTHRITIC CARTILAGE

Completed

• Conditions: cartilage degeneration; osteoarthritis; 10023213

• Registration Number: NL-OMON56915
• Lead Sponsor: Moleculaire Epidemiologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 400

Inclusion Criteria

- Patients above 40 years of age that are eligable for a total knee or hip replacement.
- Joint replacements is due to end stage osteoarthritis

Exclusion Criteria

-Patients that are obtaining a total knee or hip replacement due to other causes then osteoarthritis

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>In order to assess functional effects of OA susceptibility genes in the<br /><br>relavant disesed tissue in comparison to blood by:<br /><br><br /><br>Monitoring of RNA expression profiles in diseased tissue and blood.<br /><br>Differential allelic expression of susceptibility alleles in diseased tissue<br /><br>and blood</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Increased knowledge on the OA etiology will allow, in the future, new drugable<br /><br>targets, better prevention, prognosis and disease management.</p><br>