Comparative Evaluation of Serum Creatinine and Alkaline Phosphatase levels in Chronic Periodontitis Patients with and without Type 2 Diabetes Mellitus Before and After Scaling and Root Planing- A Clinico-biochemical Study

Aim and Objective

To evaluate and compare the serum creatinine and alkaline phosphatase levels in chronic periodontitis patients with and without T2DM.

Material and Methods

The patients selected as per the inclusion and exclusion criteria, will be allotted into 3 groups, Group A, Group B and Group C

Group A : 22 Periodontally and systemically healthy patients

Group B : 22 Chronic periodontitis patients without T2DM

     Group C : 22 Chronic  periodontitis patients with T2DM

After initial examination and taking informed consent from the patient 2ml blood with be taken followed by scaling and root planing  o the patient and blood sample will be sent to assess the serum ALP and creatinine levels.

The patient will be recalled after 4 weeks , after reviewing the periodontal status 2 ml of blood sample will be taken to assess serum ALP and creatinine.

Data collected will be compiled on to a MS Office excel worksheet & will be subjected to statistical analysis using an appropriate package like SPSS software.

Normality of numerical data will be checked using Shapiro – Wilk test or Kolmogorov-Smirnov test. Depending on the normality of data, statistical tests will be determined.

For a numerical continuous data following a normal distribution, inter group comparison (>2 groups) will be done using one way ANOVA test, else a non parametric substitute like Kruskall Wallis ANOVA test will be used.

Descriptive statistics like frequency (n) & percentage (%) of categorical data, mean & Standard deviation of numerical data in each group will be depicted & may be compared using chi square test.

Keeping alpha error at 5% and Beta error at 20%, power at 80%, p<0.05 will be considered statistically significant.