Cytokine Response in Septic Shock
试验速览
- 阶段
- 不适用
- 入组人数
- 325
- 试验地点
- 1
- 主要终点
- Cytokine response in septic shock
研究概览
简要总结
This study is designed to examine the early sequential cytokine responses during antibiotic therapy and resuscitation of septic shock in relation to clinical manifestations of disease.
The specific objective is to obtain sequential serum samples from patients with septic shock, examine a broad range of cytokine responses (TNF, IL-1, IL-6, MIF, LIF, HMGB1, etc) in a rigorous manner and correlate these responses to administration of antibiotics, resuscitative efforts and physiologic responses to illness (temp, HR, blood pressure, WBC, etc).
详细描述
Patients must be on vasopressors Patients cannot be on pressors for > 24 hrs prior to consent
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult ICU patients: . 18 years admitted with septic shock
- •Receiving Vasopressors < 24 hrs
排除标准
- •Consent refused by patient or SDM
- •Received Vasopressors > 24hrs
结局指标
主要结局
Cytokine response in septic shock
时间窗: Hours 0, 3, 6, 12, 18, 24, 36, 48, 96 and day 7
his study is designed to examine the early sequential cytokine responses during antibiotic therapy and resuscitation of septic shock in relation to clinical manifestations of disease. The specific objective is to obtain sequential serum samples from patients with septic shock, examine a broad range of cytokine responses (TNF, IL-1, IL-6, MIF, LIF, HMGB1, etc) in a rigorous manner and correlate these responses to administration of antibiotics, resuscitative efforts and physiologic responses to illness (temp, HR, blood pressure, WBC, etc).
次要结局
未报告次要终点
研究者
Dr. Anand Kumar
Attending physician/ investigator WRHA
University of Manitoba