Effect of angiotensin-converting enzyme inhibitors on systemic inflammation and myocardial sympathetic innervation in normotensive patients with type two diabetes mellitus

Heraklion University Hospital (Greece)0 个研究点目标入组 62 人开始时间: 2007年6月12日最近更新: 2021年11月8日

适应症

试验速览

2007 Results article in https://www.nature.com/articles/1002310 (added 25/10/2021)

•The study population was recruited from the Cardiology Outpatients? Department. All participants:
•1. Had type two DM (World Health Organisation criteria)
•2. Were diagnosed at an age over 30 years
•3. Had DM controlled by diet or blood glucose-lowering agents for at least six months
•4. Were normotensive (Blood Pressure [BP] less than 130/85 mmHg)
•5. Had no indications of other organic heart disease

•1. Heavy smokers
•2. Pregnant or lactating women
•3. Type one DM or secondary diabetes
•4. Previous or ongoing treatment with ACE-i, angiotensin receptor blockers, antioxidant or immunosuppressive agents
•5. Systolic BP less than 100 mmHg or diastolic BP less than 50 mmHg
•6. Poor glycaemic control
•7. Hyperuricaemia
•8. Previous history or medication for hypertension, cerebrovascular, liver or renal disease
•9. Serum potassium more than 5 mEq/L
•10. Albumin excretion rate more than 200 µg/min
•11. History of drug or alcohol abuse
•12. Any chronic inflammatory or other infectious disease during the last six months
•13. Uncontrolled hypothyroidism

发起方

Heraklion University Hospital (Greece)