ISRCTN62554526已完成4 期
Effects of an angiotensin receptor antagonist candesartan versus a calcium channel blocker amlodipine on microvascular rarefaction, endothelial dysfunction, and microalbuminuria in essential hypertension
St George's, University of London (UK)0 个研究点目标入组 46 人开始时间: 2010年5月12日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 46
研究概览
简要总结
- 2017 results in http://openaccess.sgul.ac.uk/109036/ (added 24/01/2019)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Male and female, aged 18 years or older
- •2. Uncomplicated mild-to-moderate essential hypertension, i.e., sitting diastolic blood pressure (BP) greater than or equal to 90 to less than 110 mmHg and/or systolic BP greater than or equal to 140 to less than 180 mmHg)
- •3. Not previously treated for their high blood pressure
- •4. Caucasian and light-coloured Asians only, this is due to the technical difficulty of performing capillaroscopy in dark-skinned individuals
排除标准
- •1. Malignant or accelerated hypertension
- •2. Serum creatinine greater than 180 µmol/L
- •3. Ischaemic heart disease
- •4. Cerebrovascular disease
- •5. Impaired liver functions
- •6. Diabetes mellitus
- •7. Pregnancy or risk of pregnancy
- •8. Lactation
- •9. History of alcoholism, drug abuse or other problems that are likely to invalidate the informed consent
- •10. Dark-skinned individuals (capillary microscopy can't be performed)
研究者
相似试验
已完成
不适用
Effect of an angiotensin receptor antagonist on cerebral blood flow, cerebral perfusion pressure, and systemic and peripheral haemodynamics in patients with acute strokeHypertension in acute strokeCirculatory SystemOther cerebrovascular diseasesISRCTN41456162niversity of Nottingham (UK)34
已完成
不适用
Effect of angiotensin-converting enzyme inhibitors on systemic inflammation and myocardial sympathetic innervation in normotensive patients with type two diabetes mellitusType two Diabetes Mellitus (DM)Nutritional, Metabolic, EndocrineDiabetes mellitusISRCTN76608550Heraklion University Hospital (Greece)62
进行中（未招募）
不适用
Effects of an ARB on Microcirculation in Essential HypertensioEssential hypertensionMedDRA version: 14.1Level: LLTClassification code 10004254Term: Benign essential hypertensionSystem Organ Class: 10047065 - Vascular disordersEUCTR2008-005432-32-GBSt. George's University of London (SGUL)46
已完成
4 期
Effects of angiotensin receptor blocker, Candesartan on renal function in type 2 diabetes with chronic kidney disease and hypertensiotype 2 diabetes with chronic renal disease and hypertentionJPRN-UMIN000002049Juntendo University School of Medicine100
已完成
2 期
Effects of Angiotensin-Converting Enzyme Inhibitor (Ramipril) Therapy on Blood Vessel InflammationCoronary DiseaseAtherosclerosisVasculitisNCT00005928National Heart, Lung, and Blood Institute (NHLBI)25