Renal Anemia Refractory to Erythropoietin
试验速览
- 阶段
- 不适用
- 入组人数
- 1
- 主要终点
- Renal anemia refractory to erythropoietin
研究概览
简要总结
This study evaluates the renal anemia refractory to Epo . in hemodialysis patients. all of participants will receive Epo. and identify various factors contributing to etiology of renal anemia in Epo- resistant patients.
详细描述
Chronic kidney disease (CKD) is considered a public health problem worldwide with high incidence and prevalence rates.Anemia is one of the most frequent early complication of CKD. The main cause is erythropoietin (EPO) deficiency due to impaired kidney function However, other causes should be considered when the severity of anemia is inconsistent with the decrease in renal function; when there is evidence of iron deficiency or matching decreases in hemoglobin, leukopenia and/or thrombocytopenia are also found
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients greater than or equal to 18 years old with CKD on hemodialysis
排除标准
- •Evidence of infections especial of vascular access .
- •malnutrition and manifestation of iron, B12, folate and protein deficiency .
- •any underling cause as;
- •Hematologic malignances -Hemolytic anemia -
- •Aplastic anemia (infection and/or bleeding with anemia)
- •Solid tumors
- •Bleeding (skin ,mucosal ,orificial)
- •Evidence of mineral bone disease (CKD-MBD)
结局指标
主要结局
Renal anemia refractory to erythropoietin
时间窗: 1 months
1 .Measurement of Hemoglobin , feritin and reitculocyte of patient before treatmeant by Epo. 100IU per Kg per week-SC. 2- Assessment to measure of hemoglobin of patient after treatment
次要结局
- Renal anemia refractory to erythropoietin(6MONTHS)
研究者
zaher alwi hadi
Assistant Lecturer
Assiut University