Impact of Resveratrol on Brain Function and Structure

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Dietary Supplement: Placebo; Dietary Supplement: resveratrol supplementation

• Registration Number: NCT02621554
• Lead Sponsor: Max Planck Institute for Human Cognitive and Brain Sciences

Brief Summary

The study will investigate whether resveratrol could provide positive effects on memory and brain structures and functions in healthy elderly participants.

Detailed Description

Cell and animal studies postulated various beneficial effects of resveratrol, ranging from a reduction of inflammatory processes and the treatment of cancer to the prevention of cardiovascular diseases and stroke. With regard to cognitive decline, rodent models for Alzheimer's disease (AD) showed improved learning and decelerated hippocampal neurodegeneration after intake of resveratrol.

Animal and first human studies provided evidence that resveratrol might serve as an easy, cost-effective option to develop novel prevention and treatment strategies against age-associated cognitive decline. To test this hypothesis, the researchers study general brain structure and function on healthy older individuals (\> 60years old).

Study Timeline

• Study First Submitted: 2015-11-06
• Study First Submitted QC: 2015-12-01
• Study First Posted: 2015-12-03
• Study Start: 2016-04
• Primary Completion: 2017-01
• Study Completion: 2017-01
• Status Verified: 2017-02
• Last Update Submitted: 2017-02-06
• Last Update Posted: 2017-02-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• subjects who are healthy or with subjective memory complaints
• older than 60 years old
• normal to overweight participants (BMI: 22-40 kg/sqm)

Exclusion Criteria

• dementia
• Psychiatric diseases
• severe untreated internal diseases
• diabetes
• younger than 60 years
• BMI < 22 or >40

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
placebo supplementation	Placebo	Dietary Supplement: Placebo
resveratrol supplementation	resveratrol supplementation	Dietary Supplement: Resveratrol

Primary Outcome Measures

Name	Time	Method
Change from baseline Verbal Learning Task Scores at 6 months	Baseline (timepoint 0), after 6 months (timepoint 6 months)

Secondary Outcome Measures

Name	Time	Method
Change from baseline Verbal Learning Task Scores at 12 months	after 12 months (timepoint 12 months)
Mini Mental State Examination	Baseline (timepoint 0), after 6 months (timepoint 6 months) and after 12 months (timepoint 12 months)
Structural changes on the brain MRI images	Baseline (timepoint 0), after 6 months (timepoint 6 months) and after 12 months (timepoint 12 months)
Functional changes on the brain MRI images	Baseline (timepoint 0), after 6 months (timepoint 6 months) and after 12 months (timepoint 12 months)
Plasma biomarkers	Baseline (timepoint 0), after 6 months (timepoint 6 months) and after 12 months (timepoint 12 months)

Trial Locations

Locations (1)

Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences; 🇩🇪 Leipzig, Germany