The effect of resveratrol in red wine on cognitive function in older adults: Preliminary study

Phase 1

Completed

• Conditions: Cognitive function in older adults; Absorption rates of resveratrol; Alternative and Complementary Medicine - Herbal remedies; Mental Health - Studies of normal psychology, cognitive function and behaviour

• Registration Number: ACTRN12611001288910
• Lead Sponsor: Swinburne University of Technology

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-12-16
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Participants who meet the following eligibility criteria will be recruited in the trial:

1.Healthy non-smoking males and females aged 65 or older.

2. No history of anxiety, depression or epilepsy.

3. Not taking any form of medication within 5 days of participation in the study (except for prophylactic antibiotics, or other routine medications to treat benign conditions, such as antibiotics to treat acne) and agree not to take any medication throughout the study.

4. Are willing and able to participate in all scheduled visits, treatment plan, dietary restrictions, tests and other trial procedures according to the protocol. Also comfortable with computers.

5. Understand the rating scales and computer tests (as judged by the study coordinator)

6.Provide a personally signed and dated informed consent indicating that the participant has been informed of all pertinent aspects of the trial.

Exclusion Criteria

Participants presenting with any of the following will not be included in the trial:

1.Cigarette smoker

2.Heavy drinker of alcohol (averages more than 2 standard drinks per day).

3.History of anxiety, depression, psychiatric disorders or epilepsy

4.Currently taking (or have taken in the last 4 weeks) any anticoagulant or anti-platelet medications (such as warfarin, aspirin and others)

5.Currently taking any illicit drugs and/or a history of substance abuse.

6.Allergies to any treatment products

7.Current participation in any other trials involving investigational or marketed products within 30 days prior to the practice day.

8.Any clinically relevant abnormalities in a volunteer’s medical history, physical examination, or results of laboratory tests.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess the effects of a daily moderate amount of resveratrol-enhanced red wine on cognitive performance in older adults using the Cognitive Demand Battery (CDB) which consists of the serial three subtraction task, serial seven subtraction task and the Rapid Visual Information Processing Task[- At Baseline participants will complete 2 repetitions of the CDB<br>- 45 minutes post dose participants will complete 6 repetitions of the CDB]

Secondary Outcome Measures

Name	Time	Method
To determine whether the dose of resveratrol (100 mg) is significant enough to reach detectable concentrations in the body.[10mL of blood will be taken a total at baseline, 45 minutes post dose, 105 minutes post dose and 135 minutes post dose.]