Beneficial Effect of Adding Pentoxifylline to Processed Semen Samples on ICSI Outcome in Infertile Males

Not Applicable

Completed

• Conditions: Pentoxifylline Allergy
• Interventions: Other: effect of pentoxifylline on ICSI outcome

• Registration Number: NCT01793272
• Lead Sponsor: Adam International Hospital

Brief Summary

To evaluate the effect of pentoxifylline used in preparation of semen samples that will be used for ICSI in infertile men complaining of mild and moderate asthenozoospermia (i.e. cases which does not need motility enhancement prior to ICSI) in comparison to semen samples without pentoxifylline preparation on the outcome of ICSI.

Detailed Description

The primary outcome measures were the number of oocytes retrieved, the number of oocytes injected, number of oocytes fertilized, fertilization rate, number of embryos and their quality (G1: good embryos, G2: fair embryos and G3: bad embryos), number of embryos transferred (ET), number of embryo sacs, embryo implantation rate, pregnancy rate and abortion rate for all 3 groups and pregnancy rate and abortion rate for both group (I) and group (II).

Study Timeline

• Study Start: 2010-10
• Primary Completion: 2011-04
• Study Completion: 2011-10
• Status Verified: 2013-02
• Study First Submitted: 2013-02-14
• Study First Submitted QC: 2013-02-14
• Last Update Submitted: 2013-02-14
• Study First Posted: 2013-02-15
• Last Update Posted: 2013-02-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• seeking ICSI for infertility

Exclusion Criteria

• Pyospermia, presence of antisperm antibodies. Azoospermia, severe male factor, severe asthenozoospermia. Past history of orchitis. Patients who received empirical treatment for asthenozoospermia e.g. oral Pentoxifylline, l-carnitine or antioxidants during the past 3 to 6 month. Diabetics, hypertensives or patients with any other chronic systemic illnesses. Wife's age more than 35 years. Low antral count. Presence of any ovarian factor contributing to infertility e.g. polycystic ovaries.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Pentoxifylline	effect of pentoxifylline on ICSI outcome	effect of pentoxifylline on ICSI outcome

Primary Outcome Measures

Name	Time	Method
ICSI outcome	from October 2010 to April 2011.

Trial Locations

Locations (1)

Adam International Hospital; 🇪🇬 Giza, Egypt