Effect of Pentoxifylline treatment on quality of life and change in arm circumference compared to placebo in patients with cancer cachexia: A double-blind, randomized, placebo-controlled trial
Not Applicable
- Conditions
- Malignant neoplasm.Malignant neoplasm, without specification of site
- Registration Number
- IRCT2013081410297N2
- Lead Sponsor
- Vice chancellor for research, Isfahan University of medical sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 70
Inclusion Criteria
Inclusion criteria are: 1. Histologic or cytologic proof evidencing cancers, 2. Incurable malignancy with a life expectancy=4 months, 3. Weight loss perceived by the patient as a problem, 4. Patient should be alert and mentally competent. Exclusion criteria are: 1. Affliction with edema or ascites, 2. Adrenal corticosteroids treatment (except for dexamethasone during chemotherapy) androgens, progestational agents, or other appetite stimulants within the previous month, 3. Brain metastases, 4. Pregnancy or lactation, 5. Mechanical obstruction of the alimentary tract, 6. Malabsorption, or intractable vomiting, 7. Poorly controlled hypertension or congestive heart failure.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Arm circumference. Timepoint: before and two months after intervention. Method of measurement: Meter calibrated.;Quality of life. Timepoint: before and two months after intervention. Method of measurement: SF-36 standard questionnaire.
- Secondary Outcome Measures
Name Time Method Side effects. Timepoint: during treatment. Method of measurement: clinical observation (nausea / vomiting / tachycardia).