The Stockholm Sleepy Brain Study: Effects of Sleep Deprivation on Cognitive and Emotional Processing in Young and Old
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 98
- Locations
- 1
- Primary Endpoint
- Blood oxygen level-dependent response in amygdala to angry faces (t/z-score from statistical parametric mapping)
Study Overview
Brief Summary
The main purpose of this study is to investigate the effects of partial sleep deprivation (PSD) on resting state brain connectivity, emotional contagion, empathy, and emotional regulation.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- Single (Investigator)
Eligibility Criteria
- Ages
- 20 Years to 75 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •20-30 years of age, inclusive OR 65-75 years of age, inclusive
- •Able to understand spoken and written Swedish (in order to understand instructions)
- •Normal or corrected-to-normal vision not using glasses
- •Not colour blind
- •Right-handed
- •Free from ferromagnetic objects in body
- •No history of any neurologic or psychiatric illness including drug abuse
- •No history of diabetes nor hypertension
- •No depression according to ratings using the Hospital Anxiety and Depression scale (HAD)
- •No insomnia according to ratings using the Insomnia Severity Index (ISI) and Karolinska Sleep Questionnaire (KSQ)
- •No use of psychotropic drugs
- •Not studying or working in medicine, psychology, nor behavioural science
- •Not suffering from severe seasonal allergy
- •No use of cortisone, anti-histamines, nor any other immune-modulating drugs
- •Habitual intake of no more than 4 cups of coffee per day or the equivalent in terms of caffeine
- •No daily use of nicotine
Exclusion Criteria
- Not provided
Arms & Interventions
Sleep deprivation
Partial sleep deprivation allowing 3 h sleep at night
Intervention: Partial sleep deprivation allowing 3 h sleep at night (Behavioral)
Full sleep
Sleep with no restriction
Intervention: Full sleep (Behavioral)
Outcomes
Primary Outcomes
Blood oxygen level-dependent response in amygdala to angry faces (t/z-score from statistical parametric mapping)
Time Frame: Change between 1st and 2nd MRI scanning session (approx. 1 month later)
This registration is made in order to pre-specify hypotheses in a basic science project. For a full list of outcomes and hypotheses, see study description (above).
Secondary Outcomes
No secondary outcomes reported
Investigators
Mats Lekander
Professor
Karolinska Institutet