Metabolic and Cognitive Effects of Sleep Deprivation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sleep Deprivation
- Sponsor
- Uppsala University
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Memory tasks
- Last Updated
- 11 years ago
Overview
Brief Summary
The purpose of this study is to determine whether partial sleep deprivation, as compared with normal sleep, influences certain metabolic and cognitive parameters, related to food intake, hunger and memory functions, when participants are shielded from external time cues.
Detailed Description
It is predicted that partial sleep deprivation negatively affects the hormonal status, e.g. upregulating ghrelin and other hunger-promoting hunger hormones, while showing impaired memory functions. It is also predicted that participants will tend to increase their desired portion sizes after partial sleep deprivation, compared with after a normal night's sleep.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age 20-28y
- •Healthy (self-reported) and not on medication
- •Non-smoking
- •Normal sleep-wake rhythm (i.e. 7-8 h per night, self-reported and verified by sleep diaries)
- •Normal dietary habits (regular meal pattern with daily breakfast)
Exclusion Criteria
- •Major illness
- •Taking any serious medications
- •Any sleep conditions (e.g. irregular bedtimes, sleep complaints)
- •Any dietary issues with the food items provided
- •A history of endocrine, neurological or psychiatric disorders
- •Shift work in the previous 3 months
- •Travel over several time zones within the previous two months
Outcomes
Primary Outcomes
Memory tasks
Time Frame: Change in memory performance between learning (at 2230 hours in NS and PSD condition) before going to sleep, and at 0800 and 0930 hours (following PSD or NS)
Procedural memory performance after learning a procedural memory task close to going to bed, followed by either partial sleep deprivation (PSD) or normal sleep (NS), and comparing the performance the following morning at two time points. Participants spatial memory performance in the morning at two time points, following PSD will also be compared with that following NS, after having learned such a memory task in the evening before going to bed.
Secondary Outcomes
- Circulating hormone levels(Change in circulating hormone levels and other metabolism-linked and neurodegeneration-associated molecules at 0730, 0830, 0910, 0925, 0940, 1010, 1040, 1105, and 1150 hours following the respective nighttime intervention and after the interference task)
- Intake task(Change in intake at around 1200 hours, following the respective nighttime intervention (NS or PSD))
- Working memory function task(Change in memory performance at 0800 hours and after the interference task again at 0930 hours (between and following PSD or NS))
- Portion Size Task(Change in selected portion size from baseline (at 0800 hours following the nighttime intervention), to one hour later, i.e. after an interference task)