The Stockholm Sleepy Brain Study: Effects of Sleep Deprivation on Cognitive and Emotional Processing in Young and Old

Mats Lekander1 site in 1 country98 target enrollmentNovember 2012

ConditionsSleep Deprivation

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Sleep Deprivation
Sponsor: Mats Lekander
Enrollment: 98
Locations: 1
Primary Endpoint: Blood oxygen level-dependent response in amygdala to angry faces (t/z-score from statistical parametric mapping)
Status: Completed
Last Updated: 9 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The main purpose of this study is to investigate the effects of partial sleep deprivation (PSD) on resting state brain connectivity, emotional contagion, empathy, and emotional regulation.

Registry

clinicaltrials.gov

Start Date

November 2012

End Date

May 2014

Last Updated

9 years ago

Study Type

Interventional

Study Design

Crossover

Sex

All

Investigators

Sponsor

Mats Lekander

Responsible Party

Sponsor Investigator

Principal Investigator

Mats Lekander

Professor

Karolinska Institutet

Eligibility Criteria

Inclusion Criteria

•20-30 years of age, inclusive OR 65-75 years of age, inclusive
•Able to understand spoken and written Swedish (in order to understand instructions)
•Normal or corrected-to-normal vision not using glasses
•Not colour blind
•Right-handed
•Free from ferromagnetic objects in body
•No history of any neurologic or psychiatric illness including drug abuse
•No history of diabetes nor hypertension
•No depression according to ratings using the Hospital Anxiety and Depression scale (HAD)
•No insomnia according to ratings using the Insomnia Severity Index (ISI) and Karolinska Sleep Questionnaire (KSQ)

Exclusion Criteria

Not provided

Outcomes

Primary Outcomes

Blood oxygen level-dependent response in amygdala to angry faces (t/z-score from statistical parametric mapping)

Time Frame: Change between 1st and 2nd MRI scanning session (approx. 1 month later)

This registration is made in order to pre-specify hypotheses in a basic science project. For a full list of outcomes and hypotheses, see study description (above).