The Stockholm Sleepy Brain Study: Effects of Sleep Deprivation on Cognitive and Emotional Processing in Young and Old
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 98
- 试验地点
- 2
- 主要终点
- Blood oxygen level-dependent response in amygdala to angry faces (t/z-score from statistical parametric mapping)
研究概览
简要总结
The main purpose of this study is to investigate the effects of partial sleep deprivation (PSD) on resting state brain connectivity, emotional contagion, empathy, and emotional regulation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 20 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •20-30 years of age, inclusive OR 65-75 years of age, inclusive
- •Able to understand spoken and written Swedish (in order to understand instructions)
- •Normal or corrected-to-normal vision not using glasses
- •Not colour blind
- •Right-handed
- •Free from ferromagnetic objects in body
- •No history of any neurologic or psychiatric illness including drug abuse
- •No history of diabetes nor hypertension
- •No depression according to ratings using the Hospital Anxiety and Depression scale (HAD)
- •No insomnia according to ratings using the Insomnia Severity Index (ISI) and Karolinska Sleep Questionnaire (KSQ)
- •No use of psychotropic drugs
- •Not studying or working in medicine, psychology, nor behavioural science
- •Not suffering from severe seasonal allergy
- •No use of cortisone, anti-histamines, nor any other immune-modulating drugs
- •Habitual intake of no more than 4 cups of coffee per day or the equivalent in terms of caffeine
- •No daily use of nicotine
排除标准
- 未提供
研究组 & 干预措施
Full sleep
Sleep with no restriction
干预措施: Full sleep (Behavioral)
Sleep deprivation
Partial sleep deprivation allowing 3 h sleep at night
干预措施: Partial sleep deprivation allowing 3 h sleep at night (Behavioral)
结局指标
主要结局
Blood oxygen level-dependent response in amygdala to angry faces (t/z-score from statistical parametric mapping)
时间窗: Change between 1st and 2nd MRI scanning session (approx. 1 month later)
This registration is made in order to pre-specify hypotheses in a basic science project. For a full list of outcomes and hypotheses, see study description (above).
次要结局
未报告次要终点
研究者
Mats Lekander
Professor
Karolinska Institutet