Assessment of Hematologic Indices in Juvenile Lupus Erythematosus Patients:Correlation With Disease Activity and Chronic Organ Damage in These Patients

Recruiting

• Conditions: Juvenile Systemic Lupus Erythematosus

• Registration Number: NCT06718283
• Lead Sponsor: Sohag University

Brief Summary

The study aim to evaluate the relationship between some important hematologic indices in juvenile lupus erythematosus patients and if these indices may be use as markers of disease acitivity in these patients or not ,also evaluate the relationship with these markers and chronic organ damage index

Detailed Description

We calculate important hematologic indices in children diagnosed as SLE as systemic inflamatory index ,systemic inflamatory response index and aggregate index of systemic inflamation in these patients ,and correlate these indices with SLE disease activity index and chronic damage index in these patients.

Study Timeline

• Study First Submitted: 2024-11-25
• Study Start: 2024-11-30
• Status Verified: 2024-12
• Study First Submitted QC: 2024-12-04
• Last Update Submitted: 2024-12-04
• Study First Posted: 2024-12-05
• Last Update Posted: 2024-12-05
• Primary Completion: 2025-10-15
• Study Completion: 2026-02-02

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• patients who fillful 2012 SLICC criteria or 2019 ACR/EULAR criteria of systemic lupus erythematosus
• Age of patients at disease onset before 18 years

Exclusion Criteria

• Adult onset disease ( age at disease onset after 18 years
• Any other chronic inflamatory disorders or other autoimmune diseases

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Calculation of hematological indices in juvenile lupus erythematosus patients	3_ 6 months	Calculation of systemic inflamatory index,systemic information response index and aggregate index of systemic inflamation ,and correlate these indices to SLE disease activity index
Correlation between hematologic indices in juvenile lupus erythematosus patients and disease activity in these patients	3-6 months	SLEDAI score in juvenile lupus erythematosus patients

Secondary Outcome Measures

Name	Time	Method
Calculation of chronic damage index in juvenile lupus erythematosus patients	3_6 months	SLICC/ACR score in juvenile lupus erythematosus patients
Relationship between hematologic index and chronic organ damage index in juvenile lupus erythematosus patients	3-6 months	SLICC/ACR score

Trial Locations

Locations (1)

Faculty of medicine; 🇪🇬 Sohag, Egypt