The Development and Evaluation of Multi-domain Attention Training for Older Adults With Mild Cognitive Impairment
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 60
- Primary Endpoint
- Change in attention as measured by the Digit Span Task (DS).
Study Overview
Brief Summary
This study sought to investigate the changes in attention in older adults with mild cognitive impairment after Multi-domain Attention Training .
Detailed Description
This double-blind randomized controlled study has a 2-arm parallel group design. All subjects will be randomized by the block randomization, into intervention group (Multi-domain Attention Training, MAT), or active control group (Passive information activities, PIA). Training sessions of the MAT group are 45 minutes/day, 3 days/week, for 12 weeks (36 sessions each). The training of PIA group is the same as MAT group. The investigators constructed a rigorous MAT program adhering to the Consolidated Standards of Reporting Trials (CONSORT) reporting guidelines. The investigators expect to determine the improvement in attention function of older adults with mild cognitive impairment after using the MAT program.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- Double (Participant, Outcomes Assessor)
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Participants must endorse at least two items from a list of frequent subjective memory complaints by patient and/or an informant
- •Objective memory impairment on neuropsychological tests of memory 1.5 SD or more below age/education norms
- •Clinical neurologic examination by the Mini-Mental State Examination (MMSE) score of 24 or higher
- •No impairment in personal activities of daily living (P-ADL) as determined by clinical interview with participant and family
Exclusion Criteria
- •The clinical diagnosis of dementia was based on the DSM-IV-TR
- •Active in another cognitive or memory-related training in the past year
- •Comorbid medical conditions that would predispose them to imminent functional decline or cognitive impairment
- •A diagnosis of major neurological or psychiatric illness history and/or behavioral problems that would sufficiently impair performance to make participation impossible
- •Severe losses in vision, hearing, or communicative ability
Arms & Interventions
Multi-domain Attention Training (MAT)
Training sessions of the MAT group is 45 minutes/day, 3 sessions/week, for 12 weeks (36 sessions).
Intervention: Multi-domain Attention Training (MAT) (Behavioral)
Passive information activities (PIA)
The training sessions of PIA is the same as MAT group (45 min/day, 3 days/week, for 12 weeks, for a total of 36 sessions).
Intervention: Passive information activities (PIA) (Behavioral)
Outcomes
Primary Outcomes
Change in attention as measured by the Digit Span Task (DS).
Time Frame: Change from baseline in executive attention at Immediate post-test, 3 months, 6 months after intervention.
The primary outcome indicators is executive attention assessed by the Digit Span Task (DS).
Secondary Outcomes
- Change in attention as measured by the Trail Making Test (TMT).(Change from baseline in spatial orienting attention at Immediate post-test, 3 months, 6 months after intervention.)
Investigators
Yang, Hui-Ling
Ph.D. candidate
Ministry of Science and Technology, Taiwan