Quantitative MRI for Blood Brain Barrier integrity Assessment without Gadolinium Based Contrast Agents
- Conditions
- Hersenscan gebruikmakend van contrastparametric mapping in predicting the post-contrast enhancement in brain matter
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 230
Age => 18 year
Patients from these pathologies will be included:
* Brain Tumors.
Rationale: Contrast MRI is instrumental in detecting brain tumors, as these
agents help to delineate tumor margins, show the vascular supply, and highlight
areas of neovascularity or breakdown of the normal blood-brain barrier.
* Infections.
Rationale: In cases of brain infections like abscesses, encephalitis, or
meningitis, contrast MRI can help in defining the extent of the infection and
differentiating it from other pathologies.
* Multiple Sclerosis (MS).
Rationale: For MS, contrast MRI can help in identifying active versus inactive
lesions. Active lesions will typically take up the contrast agent due to the
breakdown of the blood-brain barrier.
* Inflammatory Conditions.
Rationale: Diseases like sarcoidosis or autoimmune disorders such as vasculitis
may also be evaluated with contrast MRI to understand the extent of
inflammation and its effects on brain tissue.
* Demyelinating Diseases.
Rationale: Besides MS, other demyelinating conditions might also show contrast
enhancement where there is active inflammation.
* Metastasis.
Rationale: Contrast MRI helps in the detection of metastatic cancer to the
brain, often revealing multiple lesions with a characteristic appearance.
* Post-Treatment Evaluation.
Rationale: Following surgery, radiation, or chemotherapy, contrast MRI can help
in monitoring for recurrence or progression of disease.
Patients with other pathologies even those which contrast agent is usually
prescribed such as vascular malformations, aneurysms, congenital malformations
and other vascular anomalies are excluded.
A patient who meets any of the following criteria will be excluded from
participation in this study:
* Subjects with a typical contra-indication to an MRI exam.
* Subjects with metal implants.
* Subjects who have a documented allergy to MRI contrast media or a
contra-indication for contrast-media or will not undergo contrast-enhanced MRI.
* Woman who are pregnant or lactating
* Having any physical or mental status that interferes with the informed
consent procedure
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method