Measuring blood-brain barrier integrity non-invasively with MRI

Recruiting

• Conditions: dementia; early cognitive decline; 10012272; 10003216

• Registration Number: NL-OMON53975
• Lead Sponsor: Amsterdam UMC

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

Inclusion criteria of the COGA study includes all patients who consent to their
data being released for scientific research, by signing the informed consent
for the general protocol (METC 2017.148)

Exclusion Criteria

Contraindications for MRI, such as claustrophobia or the presence of metal in
the body.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are the exchange time maps, measured in ms (as a<br /><br>surrogate measure of permeability).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Quantified perfusion maps in the units mL/100gm/min, and arterial transit time<br /><br>maps, also measured in ms, reflecting the amount of time spins take to travel<br /><br>from the labeling plane to imaging plane.</p><br>