Cryospray Therapy for Benign Airway Stenosis: a Pilot Study (Pilot-CRYOSTASIS)
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Stenosis Trachea
- Sponsor
- Virginia Commonwealth University
- Enrollment
- 12
- Locations
- 1
- Primary Endpoint
- Degree of re-stenosis
- Status
- Recruiting
- Last Updated
- 4 months ago
Overview
Brief Summary
This is a clinical evaluation to assess the effectiveness of cryospray therapy used in addition to current standard of care endoscopic therapies in preventing short term recurrent airway stenosis with a multicentric outcome evaluation. The investigators hypothesize that the addition of SCT to standard endoscopic treatment of benign airway stenosis will result in decreased stenosis recurrence at 6 months as estimated by quantitative radiologic assessment of the stenotic volume.
Detailed Description
Spray cryo treatment of tracheal stenosis has the potential for long-lasting endoscopic management of BCAS and is used as part of routine clinical care by many physicians, but there is a relative paucity of peer-reviewed data, and no randomized controlled trial has been performed. Thus, the study could potentially show that the use of spray cryo therapy could allow patients to undergo fewer procedures to treat this condition, or lengthen the amount of time required in between these procedures, or play a role in the resolution of this condition.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Referral to interventional pulmonology or otorhinolaryngology or thoracic surgery for endoscopic management of suspected benign tracheal stenosis.
- •Significant tracheal stenosis defined by stenosis ≥ 50% of tracheal lumen assessed on chest CT or previous bronchoscopy
- •Able to provide informed consent.
- •Age \> 18
Exclusion Criteria
- •Inability to provide informed consent
- •Pregnancy
- •Known or suspected malignant central airway stenosis
- •Patient has already been enrolled in this study.
- •Study subject has any disease or condition that interferes with safe completion of the study including:
- •Hypoxemia with need for supplemental oxygen ≥ 2L/min by nasal canula
- •Pneumothorax in the previous 12 months
- •Severe COPD (defined as a FEV1/FVC \< 70% and FEV1 \<30% predicted) and/or severe persistent asthma.
- •Hemodynamic instability with systolic blood pressure \<90 mmHg or heart rate \> 120 beats/min, unless deemed to be stable with these values by the attending physicians.
- •Compromised tissue where significant ulceration or mucosal break is evident in the ablation area or adjacent organs.
Outcomes
Primary Outcomes
Degree of re-stenosis
Time Frame: 6 months
The degree of re-stenosis at 6 months expressed as the percentage of airway lumen volume within the stenotic segment at 6 months compared to personal best patency volume on CT scan performed within five weeks of the study intervention.
Secondary Outcomes
- Change in Peak Expiratory Flow (PEF)(Continous for 6 months)
- Clinical Chronic Obstructive Pulmonary Disease Questionnaire (CCQ)(2 weeks before procedure, 2 weeks after the procedure, the 3 month study mark, the 6 months study mark,)
- Incidence of complications between groups(Continous for 6 months)