The association between aging or chronic diseases and mitochondrial oxygenation and oxygen consumption as measured with the Protoporphyrin IX Triplet State Lifetime Technique
- Conditions
- Verouderingagingseniority
- Registration Number
- NL-OMON51166
- Lead Sponsor
- Anesthesiologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 319
Healthy volunteers
In order to be eligible to participate in this study, a subject must meet all
of the following criteria:
- Aged between 18 years of age and 90 years of age
- Acceptable proficiency of the Dutch language
- Healthy volunteers without physical or mental illness
Comorbidity group
In order to be eligible to participate in this study, a subject must meet all
of the following criteria:
- Aged between 18 years of age and 90 years of age
- Acceptable proficiency of the Dutch language
- One of the underlying illnesses: neurodegenerative disease, diabetes mellitus
type II or obesity (BMI>30), no other relevant comorbidity
A potential subject who meets any of the following criteria will be excluded
from participation in this study:
- Porphyria
- Known intolerance to components of the ALA plaster
- Presence of mitochondrial disease
- Pregnancy/lactation
- Patients with skin lesions on the measurement location which impede
measurements
- Incapability to provide inform consent, due to a mental condition interfering
with the ability to understand the provided information
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>MitoPO2 (mmHg). Ten mitoPO2 (mmHg) baseline measurements will be performed on<br /><br>both the sternum and upper arm of all subjects. The mean and standard deviation<br /><br>of those measurements will compute the baseline mitoPO2 for every participant.</p><br>
- Secondary Outcome Measures
Name Time Method <p>MitoVO2 (mmHg/second). Applying pressure on the probe will cause a temporary<br /><br>halt of circulation to the mitochondria. As the oxygen consumption continues,<br /><br>this will result in a time-dependent decrease in mitoPO2 from which the mitoVO2<br /><br>can be calculated in mmHg/second. Three mitoVO2 measurements will be performed<br /><br>on both the sternum and the upper arm and the mean will be calculated for both.</p><br>