Aging, chronic disease, mitoPO2 and mitoVO2

Recruiting

• Conditions: Diabetes Mellitus type II, Obesity, and Neurodegenerative diseases

• Registration Number: NL-OMON25614
• Lead Sponsor: Erasmus Medical Center Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 319

Inclusion Criteria

Healthy Volunteers
- Aged = 18 and = 90 years old
- Acceptable proficiency of the Dutch language
- Healthy volunteers without physical or mental illness

Comorbidity group
- Aged = 18 and = 90 years old
- Acceptable proficiency of the Dutch language
- One of the underlying illnesses: neurodegenerative disease, diabetes mellitus type II
or obesity (BMI>30), no other relevant comorbidity

Exclusion Criteria

- Porphyria
- Known intolerance to components of the ALA plaster
- Presence of mitochondrial disease
- Pregnancy/lactation
- Patients with skin lesions on the measurement location which impede measurements
- Incapability to provide inform consent, due to a mental condition interfering with the ability to understand the provided information

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
- To investigate the association between age and mitoPO2 values

Secondary Outcome Measures

Name	Time	Method
- To investigate the association between age and mitoVO2 values.<br>- To examine the association between diabetes, obesity and neurodegenerative disease and mitoPO2/mitoVO2 values.<br>- To compare mitoPO2 and mitoVO2 measurements performed on the sternum as opposed to the mitoPO2 and mitoVO2 measurements performed on the upper arm