Effects of Desflurane on the Quality of Anesthesia Recovery Period in Patients Undergoing Endonasal Endoscopic Pituitary Adenoma Resection#a Randomized Controlled Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 112
- 试验地点
- 1
- 主要终点
- Time required of the Aldrete score reached 9 points after drug withdrawal.
研究概览
简要总结
Nasal packing is required after endoscopic pituitary adenoma resection. The patient can only breathe through the mouth. The blood and secretion in the nasal cavity may be inhaled into the trachea after the operation. GH-secreting pituitary adenoma causes pharyngeal soft tissue and tongue hypertrophy. These conditions increase the risk of respiratory obstruction and hypoxemia during anesthesia recovery. Propofol total intravenous anesthesia has a rapid effect and a low incidence of nausea and vomiting. Patients anesthetized with desflurane recover quickly is conducive to early recovery of respiratory function and orientation. This study intends to compare the effects of desflurane and propofol on the quality of anesthesia recovery period in patients undergoing endonasal endoscopic pituitary adenoma resection and to provide clinical evidence for the use of desflurane in neurosurgical anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18-65 years;
- •Elective endoscopic transsphenoidal resection of pituitary adenomas;
- •ASA status I-III;
- •Informed consent signed by patients.
排除标准
- •emergency surgery;
- •complicated with cerebrovascular disease;
- •complicated with pulmonary disease, oxygen saturation below 95% without oxygen;
- •expected to retain endotracheal intubation;
- •preoperative disturbance of consciousness was not compatible with assessment;
- •complicated with primary hypothyroidism;
- •previous history of cervical surgery, burns, and radiotherapy;
- •BMI >30kg/m2;
- •invasive pituitary adenoma with Knosp grade 4.
研究组 & 干预措施
Desflurane Inhalational Anesthesia
干预措施: Desflurane (Drug)
Propofol Total Intravenous Anesthesia
干预措施: Propofol (Drug)
结局指标
主要结局
Time required of the Aldrete score reached 9 points after drug withdrawal.
时间窗: immediately after the surgery
次要结局
未报告次要终点
研究者
Ruquan Han
Professor
Beijing Tiantan Hospital