Desflurane and Anesthesia Recovery Period in Endonasal Endoscopic Pituitary Adenoma Resection

Not Applicable

Completed

• Conditions: Pituitary Neoplasms
• Interventions: Drug: Desflurane; Drug: Propofol

• Registration Number: NCT05088252
• Lead Sponsor: Beijing Tiantan Hospital

Brief Summary

Nasal packing is required after endoscopic pituitary adenoma resection. The patient can only breathe through the mouth. The blood and secretion in the nasal cavity may be inhaled into the trachea after the operation. GH-secreting pituitary adenoma causes pharyngeal soft tissue and tongue hypertrophy. These conditions increase the risk of respiratory obstruction and hypoxemia during anesthesia recovery. Propofol total intravenous anesthesia has a rapid effect and a low incidence of nausea and vomiting. Patients anesthetized with desflurane recover quickly is conducive to early recovery of respiratory function and orientation. This study intends to compare the effects of desflurane and propofol on the quality of anesthesia recovery period in patients undergoing endonasal endoscopic pituitary adenoma resection and to provide clinical evidence for the use of desflurane in neurosurgical anesthesia.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-10-05
• Study First Submitted QC: 2021-10-20
• Study First Posted: 2021-10-21
• Study Start: 2021-12-01
• Primary Completion: 2022-05-10
• Study Completion: 2022-05-31
• Status Verified: 2023-06
• Last Update Submitted: 2023-06-18
• Last Update Posted: 2023-06-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 112

Inclusion Criteria

• 18-65 years;
• Elective endoscopic transsphenoidal resection of pituitary adenomas;
• ASA status I-III;
• Informed consent signed by patients.

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Exclusion Criteria

• emergency surgery;
• complicated with cerebrovascular disease;
• complicated with pulmonary disease, oxygen saturation below 95% without oxygen;
• expected to retain endotracheal intubation;
• preoperative disturbance of consciousness was not compatible with assessment;
• complicated with primary hypothyroidism;
• previous history of cervical surgery, burns, and radiotherapy;
• BMI >30kg/m2;
• invasive pituitary adenoma with Knosp grade 4.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Desflurane Inhalational Anesthesia	Desflurane	-
Propofol Total Intravenous Anesthesia	Propofol	-

Primary Outcome Measures

Name	Time	Method
Time required of the Aldrete score reached 9 points after drug withdrawal.	immediately after the surgery

Trial Locations

Locations (1)

Ruquan Han; 🇨🇳 Beijing, Beijing, China