A clinical trial to evaluate the outcomes in terms of neurocognitive functions with the use of two most commonly used anaesthetic agents Isoflurane and Desflurane
Phase 4
Completed
- Conditions
- Health Condition 1: null- Effects of Isoflurane and Desflurane on Cognitive Dysfunction following anaesthesia
- Registration Number
- CTRI/2015/10/006245
- Lead Sponsor
- Post Graduate Institute of Medical Education and Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 200
Inclusion Criteria
Patients scheduled for minimally invasive surgery under general anaesthesia
Age between 18-65 years
American Society of Anaesthesiologists (ASA) Grade I and II patients
Patients with Glasgow Coma Scale (GCS) of 15
Exclusion Criteria
Cardiorespiratory disorders
Associated cerebral disease
Psychiatric illness
Preoperative cognitive disorders
Electrolyte and hormonal imbalance
Second operation.
Low level of education
History of drug abuse
Postoperative meningitis
Administration of high dose steroids
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome variable will be assessment of cognitive function at one week following anaesthesia. The cognitive functions will be assessed preoperatively and compared with cognitive functions at one week following anaesthesia.Timepoint: Psychological tests for evaluating cognitive functions <br/ ><br>1)preoperative <br/ ><br>2) postoperative at one week
- Secondary Outcome Measures
Name Time Method The secondary outcome variables will be <br/ ><br>a) Cognitive function at three months following anaesthesia <br/ ><br>b) Estimation of serological biomarkers of cognitive dysfunction. <br/ ><br>Timepoint: Cognitive function <br/ ><br>1) At three months postoperative <br/ ><br> <br/ ><br>Estimation of serological biomarkers <br/ ><br>1)preoperative <br/ ><br>2) postoperative after one hour following anaesthesia <br/ ><br>3) postoperative at one week