DEsflurane Versus Isoflurane for inhaLation sedation of critically ill patients
- Conditions
- Sedation of ventilated patients
- Registration Number
- DRKS00011403
- Lead Sponsor
- niversitätsklinikum des Saarlandes
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 21
Inclusion Criteria
Age >= 18 years and expected time of invasive ventilation and sedation >24 hours
Exclusion Criteria
sedation > 48 hours before start of study medication.
contra indications for administration of volatile anaesthetics (pregnancy, malignant hyperthermia)
tidal volume < 300 ml (< 200 ml if ECMO is used)
severe acute neurological illness,
head injury with significant intracranial bleeding,
high probability of diffuse axonal injury because of trauma mechanism or other accompagning injuries,
poor prognosis (expected survival time < 24 hours),
inability to follow simple verbal commands (before ICU stay)
history of deafness,
history of malignant hyperthermia of the patient or her/his Family.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Context sensitive half time, i.e. time until the concentration of the volatile anaesthetic in the expired air has decreased to 50% of baseline, measured in a sedation window (awakening test).
- Secondary Outcome Measures
Name Time Method 80% decrement time (time until the concentration of the volatile anaesthetic in the expired air has decreased to 20% of baseline);<br>time to first eye opening,<br>time to first Hand grip on command,<br>time to first movement of a specified extremity on command,<br>time to Narcotrend Stadium A (electroencephalographic anaesthesia Monitor)<br>percentage of time when the Patient was breathing spontaneously.