A study to compare the effects of desflurane and isoflurane on brain physiology, blood pressure, heart rate and recovery from anesthesia in brain tumor operation.
- Conditions
- Health Condition 1: null- Supratentorial Brain Tumours
- Registration Number
- CTRI/2018/09/015570
- Lead Sponsor
- Bangur Institute Of Neurosciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
1.Patients belonging to either sex between 20 to 60 years of age.
2.Patients with ASA physical status 1 & 2.
3.Patients with Glasgow coma scale 15.
4.Patients undergoing elective craniotomy under general anaesthesia for supratentorial tumours.
1.Patients refusal to give consent.
2.Patients with significant cardiovascular,pulmonary,renal,hepatic,endocrine or muscular disorders.
3.Patients having tumours with midline shift.
4.Patients allergic to any anaesthetic drug.
5.Patients having surgery related complications like vascular injury,massive intraoperative bleeding or injury to vital structures necessitating elective post operative mechanical ventilation.
6.Patients exposed to general anaesthesia in preceeding 7 days before the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.To compare the changes in lumbar cerebrospinal fluid pressure and cerebral perfusion pressure from baseline. <br/ ><br>2.To compare the effects of desflurane and isoflurane on intraoperative degree of dural tension and brain swelling.Timepoint: 1.Recorded every 5 minutes until the dura is opened. <br/ ><br>2.Assessed at the time of dural opening.
- Secondary Outcome Measures
Name Time Method To compare intraoperative and postoperative haemodynamics.Timepoint: Recorded every 5 minutes until the dura is opened and thereafter every 15 minutes uptil 1 hour postoperatively.;To compare postoperative recovery including emergence and extubation time.Timepoint: At the end of the operation.;To compare time taken to reach an Aldrete Score more than or equal to 9.Timepoint: After the patient is extubated and shifted to the Post Anaesthesia Care Unit.