A comparison of Desflurane and propofol in terms of inflammatory potential and impact on respiratory sytem in obese patients undergoing laparoscopic bariatric surgeries
Not Applicable
- Conditions
- Health Condition 1: E669- Obesity, unspecified
- Registration Number
- CTRI/2020/03/024154
- Lead Sponsor
- All India Institute of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. BMI >30 kg/m2
2. ASA Status II
3. Patients scheduled for elective laparoscopic bariatric surgery
Exclusion Criteria
1. Patient refusal
2. ASA III, IV
3. Known allergy to propofol
4. Impaired cardiopulmonary, hepatic, renal function
5. History of chronic inflammation or treatment with immunosuppressants
6. Malignancy
7. Active smoking
8. Obstructive or restrictive lung disease
9. Alcohol dependent currently
10. Pre-existing coagulation disorders
11. Active or resolving pulmonary or systemic infection
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare plasma concentration of interleukin (IL)-6 in patients anaesthetised with propofol and desfluraneTimepoint: prior to induction of anaesthesia (baseline), <br/ ><br>just after induction (T1) <br/ ><br>just before extubation (T3)
- Secondary Outcome Measures
Name Time Method Measurement of Airway resistance using impulse oscillometry in both groupsTimepoint: pre-operatively (On admission) <br/ ><br>post-operatively (24 hours after surgery);Respiratory parameters [Tidal volume, respiratory rate, Peak and plateau pressures, driving pressure, compliance, SpO2, PaO2/FiO2 (oxygenation)] in both groupsTimepoint: just after induction (T1) <br/ ><br>30 mins after pneumoperitoneum (T2) <br/ ><br>just before extubation (T3) <br/ ><br>