Comparison of The Effects of Sevoflurane, Desflurane and Total Intravenous Anaesthesia on Pulmonary Function Tests

Not Applicable

• Conditions: Pituitary Adenoma
• Interventions: Drug: Sevoflurane; Drug: Propofol; Drug: Desflurane

• Registration Number: NCT02709863
• Lead Sponsor: Istanbul University

Brief Summary

This study will compare the effects of sevoflurane, desflurane and total intravenous anaesthesia on pulmonary function tests in patients undergoing endoscopic endonasal transsphenoidal surgery of pituitary gland. Participants will be divided into three equal groups. The first group will receive sevoflurane, second grup will receive desflurane and third grup will receive total intravenous anaesthesia. Investigators are also going to evaluate blood gas analysis.

Detailed Description

Investigators are going to evaluate forced expiratory volume in 1st Second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, partial pressure of arterial oxygen (PaO2), partial pressure of arterial carbon dioxide (PaCO2), potential of hydrogen (pH), arterial oxygen saturation (SaO2), base excess (BE), bicarbonate (HCO3) and partial pressure of arterial oxygen/fraction of inspired oxygen (PaO2/FiO2) ratio to compare the effects of drugs.

Study Timeline

• Study Start: 2015-10
• Study First Submitted: 2016-02-23
• Status Verified: 2016-03
• Study First Submitted QC: 2016-03-10
• Last Update Submitted: 2016-03-10
• Study First Posted: 2016-03-16
• Last Update Posted: 2016-03-16
• Primary Completion: 2017-02
• Study Completion: 2017-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• American Society of Anesthesiologists (ASA) score I-II patients

Exclusion Criteria

• Significant cardiopulmonary disease,
• Diagnosed obstructive or restrictive pulmonary disease,
• Patients with chest wall deformities, liver or kidney failure,
• Postoperative lack of cooperation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sevoflurane	Sevoflurane	1-1.5 minimum alveolar concentration (MAC), inhalation route, during operation
Propofol	Propofol	6-10 mg/kg/h, iv infusion, during operation
Desflurane	Desflurane	1-1.5 minimum alveolar concentration (MAC), inhalation route, during operation

Primary Outcome Measures

Name	Time	Method
Change from baseline FEV1%predicted (no unit)	Preoperative baseline, postoperative 1st hour and postoperative 24th hour	FEV1 is measured with spirolab III colour liquid-crystal-display medical spirometer. FEV1%predicted is calculated with age, sex, height and weight input by the same equipment.

Secondary Outcome Measures

Name	Time	Method
Change from baseline FVC%predicted (no unit)	Preoperative baseline, postoperative 1st hour and postoperative 24th hour	FVC is measured with spirolab III colour liquid-crystal-display medical spirometer. FVC%predicted is calculated with age, sex, height and weight input by the same equipment.
Change from baseline FEV1/FVC ratio (no units)	Preoperative baseline, postoperative 1st hour and postoperative 24th hour	FEV1/FVC ratio is calculated by spirolab III colour liquid-crystal-display medical spirometer based on age, sex, height and weight.
Change from baseline PaO2 (mmHg)	Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour	PaO2 is a component of arterial blood gas analysis done with Cobas B221.
Change from baseline PaCO2 (mmHg)	Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour	PaCO2 is a component of arterial blood gas analysis done with Cobas B221.
Change from baseline pH	Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour	pH is a component of arterial blood gas analysis done with Cobas B221
Change from baseline SaO2 (%)	Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour	SaO2 is a component of arterial blood gas analysis done with Cobas B221
Change from baseline BE (mmol/L)	Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour	BE is a component of arterial blood gas analysis done with Cobas B221
Change from baseline HCO3 (mmol/L)	Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour	HCO3 is a component of arterial blood gas analysis done with Cobas B221
Change from baseline PaO2/FiO2 ratio (no units)	Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour	PaO2/FiO2 ratio is calculated by investigators

Trial Locations

Locations (1)

Istanbul University Cerrahpasa Medical Faculty Neurosurgery Department; 🇹🇷 Istanbul, Turkey