Propofol
- Generic Name
- Propofol
- Brand Names
- Diprivan
- Drug Type
- Small Molecule
- Chemical Formula
- C12H18O
- CAS Number
- 2078-54-8
- Unique Ingredient Identifier
- YI7VU623SF
- Background
Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.
- Indication
Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.
- Associated Therapies
- Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy
Efficacy of Esketamine Combined With Different General Anesthetics on Quality of Postoperative Recovery
- Conditions
- Quality of Postoperative Recovery
- Interventions
- Drug: normal salineDrug: etomidate-ciprofol (EC) mixtureDrug: etomidate-propofol (EP) mixture
- First Posted Date
- 2025-05-16
- Last Posted Date
- 2025-05-16
- Lead Sponsor
- Northern Jiangsu People's Hospital
- Target Recruit Count
- 190
- Registration Number
- NCT06976996
- Locations
- 🇨🇳
Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, China
Effect of Dexmedetomidine on Hemodynamics in Cardiac Surgery
- Conditions
- Use of Dexmedetomidine in Cardiac Surgery (CABG, Valve Replacement or Total Aortic Arch Replacement)
- Interventions
- First Posted Date
- 2025-05-06
- Last Posted Date
- 2025-05-06
- Lead Sponsor
- Pamukkale University
- Target Recruit Count
- 52
- Registration Number
- NCT06958913
- Locations
- 🇹🇷
Pamukkale University, Denizli, Turkey
Effect of Ciprofol on Intraoperative Hypotension in Elderly Patients Receiving Renin-angiotensin System Inhibitors
- Conditions
- Intraoperative HypotensionCiprofolRenin-angiotensin System Inhibitors
- Interventions
- First Posted Date
- 2025-05-01
- Last Posted Date
- 2025-05-01
- Lead Sponsor
- Second Affiliated Hospital, School of Medicine, Zhejiang University
- Target Recruit Count
- 140
- Registration Number
- NCT06952608
- Locations
- 🇨🇳
The Second Affiliated Hospital of Zhejiang University anesthesiology department, Hangzhou, Zhejiang, China
Endometriosis and Pain Treatment by Intraoperative Administration of Low-dose Ketamine
- First Posted Date
- 2025-04-30
- Last Posted Date
- 2025-04-30
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Target Recruit Count
- 118
- Registration Number
- NCT06951802
- Locations
- 🇨🇭
Inselspital Bern, Bern, Switzerland
This Study Evaluated the Safety of Awake Extubation in Children at Risk for Respiratory Events Undergoing General Anesthesia.
- First Posted Date
- 2025-04-20
- Last Posted Date
- 2025-04-20
- Lead Sponsor
- Selcuk University
- Target Recruit Count
- 425
- Registration Number
- NCT06936761
- Locations
- 🇹🇷
Selcuk University Faculty of Dentistry, Konya, Selcuklu, Turkey
Comparison of Sevoflurane and Propofol on ANI
- Conditions
- PropofolSevofluraneAnalgesia Nociception Index
- Interventions
- First Posted Date
- 2025-04-02
- Last Posted Date
- 2025-04-02
- Lead Sponsor
- Pusan National University Yangsan Hospital
- Target Recruit Count
- 30
- Registration Number
- NCT06907823
A Study of the Correlation Between the Debilitating State of the Elderly and Propofol Sensitivity
- First Posted Date
- 2025-03-11
- Last Posted Date
- 2025-03-11
- Lead Sponsor
- Second Hospital of Shanxi Medical University
- Target Recruit Count
- 128
- Registration Number
- NCT06870357
- Locations
- 🇨🇳
Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery
- Conditions
- AnesthesiaTooth Extraction
- Interventions
- First Posted Date
- 2025-03-10
- Last Posted Date
- 2025-03-10
- Lead Sponsor
- Albert Einstein College of Medicine
- Target Recruit Count
- 73
- Registration Number
- NCT06867068
- Locations
- 🇺🇸
NYCHHC - Jacobi Medical Center and North Central Bronx Hospital, Bronx, New York, United States
Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) Stage II
- Conditions
- Depression
- Interventions
- Diagnostic Test: Electroencephalography (EEG)Behavioral: Brief Behavioral Therapy for Insomnia
- First Posted Date
- 2025-03-10
- Last Posted Date
- 2025-03-11
- Lead Sponsor
- Washington University School of Medicine
- Target Recruit Count
- 70
- Registration Number
- NCT06867549
- Locations
- 🇺🇸
Washington University School of Medicine/Barnes-Jewish Hospital, Saint Louis, Missouri, United States
Efficacy of Propofol-Ketamine and Sevoflurane in Children Undergoing Magnetic Resonance Imaging
- Conditions
- Recovery PeriodHypoxemiaPatient Safety
- Interventions
- First Posted Date
- 2025-02-18
- Last Posted Date
- 2025-04-27
- Lead Sponsor
- Kocaeli City Hospital
- Target Recruit Count
- 180
- Registration Number
- NCT06832683
Drug Development Updates
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