Propofol
- Generic Name
- Propofol
- Brand Names
- Diprivan
- Drug Type
- Small Molecule
- Chemical Formula
- C12H18O
- CAS Number
- 2078-54-8
- Unique Ingredient Identifier
- YI7VU623SF
- Background
Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.
- Indication
Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.
- Associated Therapies
- Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy
Efficacy of Propofol-Ketamine and Sevoflurane in Children Undergoing Magnetic Resonance Imaging
- Conditions
- Recovery PeriodHypoxemiaPatient Safety
- Interventions
- First Posted Date
- 2025-02-18
- Last Posted Date
- 2025-04-27
- Lead Sponsor
- Kocaeli City Hospital
- Target Recruit Count
- 180
- Registration Number
- NCT06832683
Effect of Propofol Versus Remimazolam Intravenous Anesthesia on Respiratory Depression
- Conditions
- Respiratory Depression
- Interventions
- First Posted Date
- 2025-02-10
- Last Posted Date
- 2025-02-10
- Lead Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
- Target Recruit Count
- 96
- Registration Number
- NCT06816173
- Locations
- 🇨🇳
The second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Combination of Remimazolam and Propofol During Drug-induced Sleep Endoscopy
- Conditions
- Sedative Effect During Drug-induced Sleep EndoscopyObstructive Sleep Apnea (OSA)
- Interventions
- First Posted Date
- 2025-01-20
- Last Posted Date
- 2025-01-20
- Lead Sponsor
- Dan Liu
- Target Recruit Count
- 80
- Registration Number
- NCT06784479
- Locations
- 🇨🇳
Respiratory Endoscopy Center of Tianjin Medical University General Hospital, Tianjin, Tianjin, China
Comparison of Remimazolam and Propofol in Endoscopic Examinations and Treatments
- Conditions
- Postoperative ComplicationsRespiratory DepressionPostoperative NauseaVomitingConstipation
- Interventions
- First Posted Date
- 2025-01-16
- Last Posted Date
- 2025-05-08
- Lead Sponsor
- Kaohsiung Veterans General Hospital.
- Target Recruit Count
- 90
- Registration Number
- NCT06777758
- Locations
- 🇨🇳
Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
The Effect of General Anesthesia with Remimazolam and Propofol on Rhythmic State and Cognitive Function
- Conditions
- Cognitive FunctioningPropofolRemimazolamCircadian Rhythm
- Interventions
- First Posted Date
- 2025-01-15
- Last Posted Date
- 2025-02-14
- Target Recruit Count
- 174
- Registration Number
- NCT06775366
- Locations
- 🇨🇳
The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy
- Conditions
- Post-induction HypotensionLidocaineOpioidEmergency Laparotomy
- Interventions
- First Posted Date
- 2025-01-13
- Last Posted Date
- 2025-01-22
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 150
- Registration Number
- NCT06772727
- Locations
- 🇪🇬
Faculty of Medicine, Cairo University, Cairo, Egypt
Comparison of Safety and Efficacy for Different Sedation Regimens During Colonoscopy
- Conditions
- Deep SedationsConscious SedationColonoscopy
- Interventions
- First Posted Date
- 2025-01-08
- Last Posted Date
- 2025-01-08
- Lead Sponsor
- Qassim Health Cluster
- Target Recruit Count
- 157
- Registration Number
- NCT06763705
- Locations
- 🇸🇦
King Saud Hospital, Unaizah, Qassim, Saudi Arabia
DISE in Pediatric Sleep Disordered Breathing
- Conditions
- Sleep Disordered BreathingDrug Induced Sleep Disorder
- Interventions
- First Posted Date
- 2025-01-03
- Last Posted Date
- 2025-01-03
- Lead Sponsor
- University of Iowa
- Registration Number
- NCT06756971
Effect of Remimazolam Versus Dexmedetomidine on the Incidence of Delirium After Elective Cardiac Surgery with Cardiopulmonary Bypass: a Prospective Randomized Controlled Trial
- Conditions
- Delirium - Postoperative
- Interventions
- First Posted Date
- 2025-01-01
- Last Posted Date
- 2025-01-01
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 111
- Registration Number
- NCT06756178
- Locations
- 🇪🇬
Assiut University, Assiut, Egypt
Ketamine Sedation As Neuroprotective Agent Following Out-of-hospital Cardiac Arrest
- Conditions
- Out-of-hospital Cardiac Arrest (OHCA)
- Interventions
- First Posted Date
- 2024-12-20
- Last Posted Date
- 2024-12-20
- Lead Sponsor
- Christian Hassager
- Target Recruit Count
- 282
- Registration Number
- NCT06744361
- Locations
- 🇩🇰
Department of Cardiology, Rigshospitalet, Copenhagen, Denmark
🇩🇰Odense University Hospital, Odense C, Denmark
Drug Development Updates
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