Remimazolam
- Generic Name
- Remimazolam
- Brand Names
- Byfavo
- Drug Type
- Small Molecule
- Chemical Formula
- C21H19BrN4O2
- CAS Number
- 308242-62-8
- Unique Ingredient Identifier
- 7V4A8U16MB
- Background
Remimazolam is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation during short (<30 minute) procedures. Recent trends in anesthesia-related drug development have touted the benefits of so-called "soft drugs" - these agents, such as remifentanil, are designed to be metabolically fragile and thus susceptible to rapid biotransformation and elimination as inactive metabolites. These "soft drugs" are useful in the context of surgical procedures, wherein a rapid onset/offset is desirable, enabling anesthesiologists to manipulate drug concentrations as needed. Remimazolam was the first "soft" benzodiazepine analog to be developed and was approved for use by the FDA in July 2020 under the brand name Byfavo.
- Indication
Remimazolam is indicated for the induction and maintenance of procedural sedation in adults undergoing procedures lasting 30 minutes or less.
- Associated Conditions
- Procedural Sedation
Effect of Propofol Versus Remimazolam Intravenous Anesthesia on Respiratory Depression
- Conditions
- Respiratory Depression
- Interventions
- First Posted Date
- 2025-02-10
- Last Posted Date
- 2025-02-10
- Lead Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
- Target Recruit Count
- 96
- Registration Number
- NCT06816173
- Locations
- 🇨🇳
The second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Comparison of Remimazolam and Propofol in Endoscopic Examinations and Treatments
- Conditions
- Postoperative ComplicationsRespiratory DepressionPostoperative NauseaVomitingConstipation
- Interventions
- First Posted Date
- 2025-01-16
- Last Posted Date
- 2025-05-08
- Lead Sponsor
- Kaohsiung Veterans General Hospital.
- Target Recruit Count
- 90
- Registration Number
- NCT06777758
- Locations
- 🇨🇳
Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
The Effect of General Anesthesia with Remimazolam and Propofol on Rhythmic State and Cognitive Function
- Conditions
- Cognitive FunctioningPropofolRemimazolamCircadian Rhythm
- Interventions
- First Posted Date
- 2025-01-15
- Last Posted Date
- 2025-02-14
- Target Recruit Count
- 174
- Registration Number
- NCT06775366
- Locations
- 🇨🇳
The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
Dexmedetomidine Nasal Spray and Pediatric Bronchoscopy
- Conditions
- Fiberoptic Bronchoscopy
- Interventions
- First Posted Date
- 2025-01-01
- Last Posted Date
- 2025-05-07
- Lead Sponsor
- Tongji Hospital
- Target Recruit Count
- 200
- Registration Number
- NCT06755996
- Locations
- 🇨🇳
Tongji hospital, Wuhan, Hubei, China
Effect of Remimazolam Versus Dexmedetomidine on the Incidence of Delirium After Elective Cardiac Surgery with Cardiopulmonary Bypass: a Prospective Randomized Controlled Trial
- Conditions
- Delirium - Postoperative
- Interventions
- First Posted Date
- 2025-01-01
- Last Posted Date
- 2025-01-01
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 111
- Registration Number
- NCT06756178
- Locations
- 🇪🇬
Assiut University, Assiut, Egypt
Study on the Feelings of Euphoria Caused by Remimazolam During Gastroscopy and Colonoscopy and Their Related Factors
- Conditions
- EuphoriaRemimazolam BesylateGastrointestinal Endoscopy
- Interventions
- First Posted Date
- 2024-12-06
- Last Posted Date
- 2024-12-06
- Lead Sponsor
- Zhangjie Yu
- Target Recruit Count
- 305
- Registration Number
- NCT06721195
- Locations
- 🇨🇳
Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China
The Efficacy and Safety of Remimazolam Besylate for Cardiac Anesthesia
- Conditions
- Anesthesia
- Interventions
- First Posted Date
- 2024-12-05
- Last Posted Date
- 2024-12-05
- Lead Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
- Target Recruit Count
- 320
- Registration Number
- NCT06717945
Remimazolam Besylate in Sedation of Postcardioperative Patients
- Conditions
- RemimazolamPropofolSedationMechanical VentilationIntensive CareCardiac Surgery
- Interventions
- First Posted Date
- 2024-12-04
- Last Posted Date
- 2025-02-18
- Lead Sponsor
- First Affiliated Hospital of Zhejiang University
- Target Recruit Count
- 120
- Registration Number
- NCT06716840
- Locations
- 🇨🇳
First afflilated hospital of zhejiang university school of medicine, Hangzhou, Zhejiang, China
Comparison of General Anesthesia Hemodynamics Between R and P in Patients Undergoing Laparoscopic Hepatectomy
- First Posted Date
- 2024-12-03
- Last Posted Date
- 2024-12-03
- Lead Sponsor
- Sun Yat-sen University
- Target Recruit Count
- 88
- Registration Number
- NCT06714669
- Locations
- 🇨🇳
Sun Yat-san University Cancer Center, Guangzhou, Guangdong, China
RCT Comparing Remimazolam With Propofol Under EEG DSA Guidance During Cardiac Electrophysiology Studies and Ablation
- Conditions
- HemodynamicRemimazolamPropofolCardiac Electrophysiology
- Interventions
- Device: With intubation and controlled ventilation to maintain airwayDevice: Maintain spontaneous ventilation without intubation
- First Posted Date
- 2024-11-22
- Last Posted Date
- 2024-11-22
- Lead Sponsor
- Taipei Veterans General Hospital, Taiwan
- Target Recruit Count
- 200
- Registration Number
- NCT06700681
- Locations
- 🇨🇳
Taipei Veterans General Hospital, Taipei, Taiwan
Drug Development Updates
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