Remimazolam
- Generic Name
- Remimazolam
- Brand Names
- Byfavo
- Drug Type
- Small Molecule
- Chemical Formula
- C21H19BrN4O2
- CAS Number
- 308242-62-8
- Unique Ingredient Identifier
- 7V4A8U16MB
- Background
Remimazolam is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation during short (<30 minute) procedures. Recent trends in anesthesia-related drug development have touted the benefits of so-called "soft drugs" - these agents, such as remifentanil, are designed to be metabolically fragile and thus susceptible to rapid biotransformation and elimination as inactive metabolites. These "soft drugs" are useful in the context of surgical procedures, wherein a rapid onset/offset is desirable, enabling anesthesiologists to manipulate drug concentrations as needed. Remimazolam was the first "soft" benzodiazepine analog to be developed and was approved for use by the FDA in July 2020 under the brand name Byfavo.
- Indication
Remimazolam is indicated for the induction and maintenance of procedural sedation in adults undergoing procedures lasting 30 minutes or less.
- Associated Conditions
- Procedural Sedation
Trial Evaluating the Efficacy of Remimazolam in Endobronchial Ultrasound Guided Transbronchial Needle Aspiration
- First Posted Date
- 2024-02-23
- Last Posted Date
- 2024-02-23
- Lead Sponsor
- Yeungnam University Hospital
- Target Recruit Count
- 330
- Registration Number
- NCT06275594
- Locations
- 🇰🇷
Yeungnam University Hospital, Daegu, Namgu, Korea, Republic of
Remimazolam in High Risk ERCP Patients
- Conditions
- the Severity and Duration of Intraoperative Hypotension
- Interventions
- Drug: placebo
- First Posted Date
- 2024-02-14
- Last Posted Date
- 2024-02-16
- Lead Sponsor
- National Taiwan University Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT06258356
Ketamine for Veterans With Parkinson's Disease
- First Posted Date
- 2024-01-30
- Last Posted Date
- 2025-04-15
- Lead Sponsor
- VA Office of Research and Development
- Target Recruit Count
- 80
- Registration Number
- NCT06231563
- Locations
- 🇺🇸
San Francisco VA Medical Center, San Francisco, CA, San Francisco, California, United States
A Study of Remimazolam Tosilate for Sedation in the ICU
- Conditions
- Sedation in the ICU
- Interventions
- First Posted Date
- 2024-01-24
- Last Posted Date
- 2024-11-15
- Lead Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
- Target Recruit Count
- 214
- Registration Number
- NCT06222294
- Locations
- 🇨🇳
The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
Comparison of Remimazolam-based MAC With Inhalation General Anesthesia Under the Guidance of an ANI Monitor During TURB
- Conditions
- Patients Undergoing Transurethral Resection of Bladder
- Interventions
- Drug: general anesthesia with sevoflurane
- First Posted Date
- 2024-01-22
- Last Posted Date
- 2024-01-22
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 46
- Registration Number
- NCT06217055
- Locations
- 🇰🇷
Yonsei university college of medicine, Seoul, Korea, Republic of
A Study of Remimazolam Tosilate for Sedation in Non-intubated Diagnostic and Therapeutic Procedures
- Conditions
- Sedation in Non-intubated Diagnostic and Therapeutic Procedures
- Interventions
- First Posted Date
- 2024-01-22
- Last Posted Date
- 2024-01-22
- Lead Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
- Target Recruit Count
- 240
- Registration Number
- NCT06216444
- Locations
- 🇨🇳
Zhongshan Hospital, Fudan University, Shanghai, Shanghai, China
Comparison of Emergence Delirium: Remimazolam vs Sevoflurane Anesthesia
- Conditions
- Emergence Delirium
- Interventions
- First Posted Date
- 2024-01-19
- Last Posted Date
- 2024-01-19
- Lead Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
- Target Recruit Count
- 90
- Registration Number
- NCT06214117
- Locations
- 🇨🇳
The second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
The Effects of Remimazolam on the Incidence of Severe Hypoxia During Sedated Hysteroscopy for Assisted Reproduction in Overweight or Obese Patients
- Conditions
- HysteroscopyOverweight or ObesityHypoxia
- Interventions
- First Posted Date
- 2024-01-03
- Last Posted Date
- 2024-07-23
- Lead Sponsor
- RenJi Hospital
- Target Recruit Count
- 600
- Registration Number
- NCT06187896
- Locations
- 🇨🇳
Diansan Su, Shanghai, Shanghai, China
Effect of Remimazolam on Postoperative Delirium
- Conditions
- General Anesthetic Drug Adverse Reaction
- Interventions
- First Posted Date
- 2023-12-26
- Last Posted Date
- 2023-12-26
- Lead Sponsor
- Zhihong LU
- Target Recruit Count
- 190
- Registration Number
- NCT06180876
- Locations
- 🇨🇳
Xijing hospital, Fourth military medical university, Xi'an, Shaanxi, China
EEG Parameters Between Remimazolam- and Propofol-based Anesthesia
- Conditions
- Acalculous CholecystitisCholecystitis, AcuteGallbladder Neoplasms
- Interventions
- First Posted Date
- 2023-12-21
- Last Posted Date
- 2023-12-21
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 60
- Registration Number
- NCT06178848
- Locations
- 🇰🇷
Department of Anesthesiology and Pain Medicine Yonsei University College of Medicine, Seoul, Korea, Republic of
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.