Remimazolam
- Generic Name
- Remimazolam
- Brand Names
- Byfavo
- Drug Type
- Small Molecule
- Chemical Formula
- C21H19BrN4O2
- CAS Number
- 308242-62-8
- Unique Ingredient Identifier
- 7V4A8U16MB
- Background
Remimazolam is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation during short (<30 minute) procedures. Recent trends in anesthesia-related drug development have touted the benefits of so-called "soft drugs" - these agents, such as remifentanil, are designed to be metabolically fragile and thus susceptible to rapid biotransformation and elimination as inactive metabolites. These "soft drugs" are useful in the context of surgical procedures, wherein a rapid onset/offset is desirable, enabling anesthesiologists to manipulate drug concentrations as needed. Remimazolam was the first "soft" benzodiazepine analog to be developed and was approved for use by the FDA in July 2020 under the brand name Byfavo.
- Indication
Remimazolam is indicated for the induction and maintenance of procedural sedation in adults undergoing procedures lasting 30 minutes or less.
- Associated Conditions
- Procedural Sedation
The Study of Ciprofol for the Suppression of Cardiovascular Responses to Tracheal Intubation
- Conditions
- Intubation, IntratrachealAdverse Effects
- Interventions
- First Posted Date
- 2023-10-23
- Last Posted Date
- 2023-10-23
- Lead Sponsor
- The Second Affiliated Hospital of Hainan Medical University
- Target Recruit Count
- 150
- Registration Number
- NCT06095570
- Locations
- 🇨🇳
The Second Affiliated Hospital of Hainan Medical University, Hai Kou, China, Haikou, Hainan, China
The ED95 of Single Intravenous Bolus Remimazolam Besylate in Pediatric Patients During General Anesthesia Induction
- Conditions
- PediatricED95SedationGeneral Anesthesia
- Interventions
- First Posted Date
- 2023-09-29
- Last Posted Date
- 2025-02-07
- Lead Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
- Target Recruit Count
- 120
- Registration Number
- NCT06061159
- Locations
- 🇨🇳
The second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
COnventional Vs. Optimised PERiprocedural Analgosedation Vs. Total IntraVEnous Anaesthesia for Pulsed-Field Ablation (COOPERATIVE-PFA)
- First Posted Date
- 2023-08-28
- Last Posted Date
- 2025-02-03
- Lead Sponsor
- Charles University, Czech Republic
- Target Recruit Count
- 127
- Registration Number
- NCT06013345
- Locations
- 🇨🇿
University Hospital Kralovske Vinohrady, Prague, Czechia
The Dose Range of Remimazolam Besylate in Different Age Groups
- Conditions
- RemimazolamAnesthesia
- Interventions
- First Posted Date
- 2023-08-24
- Last Posted Date
- 2023-09-06
- Lead Sponsor
- Tongji Hospital
- Target Recruit Count
- 1876
- Registration Number
- NCT06009991
- Locations
- 🇨🇳
ongji Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan, Hubei, China
Effects of Remimazolam and Propofol on Anesthesia Induction
- First Posted Date
- 2023-08-24
- Last Posted Date
- 2024-01-25
- Lead Sponsor
- Zheng Guo
- Target Recruit Count
- 80
- Registration Number
- NCT06009055
- Locations
- 🇨🇳
econd of Shanxi Medical University, Taiyuan, Shanxi, China
The Effects of Remimazolam on the Incidence of Hypoxia During Sedated Hysteroscopy for Assisted Reproduction in Overweight or Obese Patients
- Conditions
- HypoxiaHysteroscopyOverweight or Obesity
- Interventions
- First Posted Date
- 2023-08-22
- Last Posted Date
- 2023-08-28
- Lead Sponsor
- RenJi Hospital
- Target Recruit Count
- 600
- Registration Number
- NCT06004843
- Locations
- 🇨🇳
Renji Hospital, Shanghai, Pudong New Area, China
Efficacy and Safety of Remimazolam Compared With Midazolam During Bronchoscopy:Randomised Controlled Trial
- First Posted Date
- 2023-08-16
- Last Posted Date
- 2023-08-16
- Lead Sponsor
- Chungbuk National University Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT05994547
- Locations
- 🇰🇷
Chungbuk National University Hospital, Cheongju-si, Chungcheongbuk-do, Korea, Republic of
Dose of Remi in Children
- First Posted Date
- 2023-08-14
- Last Posted Date
- 2023-08-14
- Lead Sponsor
- Zhihong LU
- Target Recruit Count
- 25
- Registration Number
- NCT05990673
Remimazolam for Cataract Surgery
- Conditions
- Cataract SurgeryCognitive Impairment
- Interventions
- First Posted Date
- 2023-08-07
- Last Posted Date
- 2025-03-19
- Lead Sponsor
- University of California, Los Angeles
- Target Recruit Count
- 120
- Registration Number
- NCT05980117
- Locations
- 🇺🇸
Ronald Reagan UCLA Medical Center, Department of Anesthesiology & Perioperative Medicine, Los Angeles, California, United States
Dose Finding Study for Remimazolam in Children
- First Posted Date
- 2023-08-03
- Last Posted Date
- 2023-11-22
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 50
- Registration Number
- NCT05975255
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
Drug Development Updates
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