Remimazolam
- Generic Name
- Remimazolam
- Brand Names
- Byfavo
- Drug Type
- Small Molecule
- Chemical Formula
- C21H19BrN4O2
- CAS Number
- 308242-62-8
- Unique Ingredient Identifier
- 7V4A8U16MB
- Background
Remimazolam is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation during short (<30 minute) procedures. Recent trends in anesthesia-related drug development have touted the benefits of so-called "soft drugs" - these agents, such as remifentanil, are designed to be metabolically fragile and thus susceptible to rapid biotransformation and elimination as inactive metabolites. These "soft drugs" are useful in the context of surgical procedures, wherein a rapid onset/offset is desirable, enabling anesthesiologists to manipulate drug concentrations as needed. Remimazolam was the first "soft" benzodiazepine analog to be developed and was approved for use by the FDA in July 2020 under the brand name Byfavo.
- Indication
Remimazolam is indicated for the induction and maintenance of procedural sedation in adults undergoing procedures lasting 30 minutes or less.
- Associated Conditions
- Procedural Sedation
The Effect of Remimazolam and Dexmedetomidine on the Incidence of Hypotension During Spinal Anesthesia
- Conditions
- Spinal AnesthesiaRemimazolam
- Interventions
- First Posted Date
- 2023-07-07
- Last Posted Date
- 2023-08-08
- Lead Sponsor
- Pusan National University Yangsan Hospital
- Target Recruit Count
- 72
- Registration Number
- NCT05935657
A Study of Remimazolam Tosilate for Prolonged Sedation in the ICU
- First Posted Date
- 2023-06-22
- Last Posted Date
- 2023-06-28
- Lead Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
- Target Recruit Count
- 20
- Registration Number
- NCT05913336
- Locations
- 🇨🇳
The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China
Effect of Sevoflurane and Remimazolam on Arterial Oxygenation During One-lung Ventilation
- Conditions
- RemimazolamOne-Lung VentilationThoracic Surgery, Video-Assisted
- Interventions
- First Posted Date
- 2023-06-18
- Last Posted Date
- 2024-08-12
- Lead Sponsor
- Pusan National University Yangsan Hospital
- Target Recruit Count
- 66
- Registration Number
- NCT05907525
- Locations
- 🇰🇷
Pusan National University Yangsan Hospital, Yangsan, Please Select, Korea, Republic of
Remimazolam for Postoperative Atrial Fibrillation
- Conditions
- RemimazolamCoronary Artery Bypass Grafting
- Interventions
- First Posted Date
- 2023-06-06
- Last Posted Date
- 2023-06-06
- Lead Sponsor
- Yangzhou University
- Target Recruit Count
- 50
- Registration Number
- NCT05891145
- Locations
- 🇨🇳
The Affiliated Hospital of Yangzhou University., Yangzhou, Jiangsu, China
Effective Dose of Remimazolam Combined With Propofol in Painless Gastroscopy
- First Posted Date
- 2023-05-25
- Last Posted Date
- 2023-08-01
- Lead Sponsor
- Sichuan Provincial People's Hospital
- Target Recruit Count
- 22
- Registration Number
- NCT05876793
- Locations
- 🇨🇳
Sichuan Provincial People's Hospital, Chengdu, Sichuan, China
The Effect of Remimazolam on Opioid Induced Hyperalgesia
- Conditions
- Hyperalgesia, Mechanical
- Interventions
- First Posted Date
- 2023-05-19
- Last Posted Date
- 2023-10-06
- Lead Sponsor
- Wonkwang University Hospital
- Target Recruit Count
- 108
- Registration Number
- NCT05866315
- Locations
- 🇰🇷
Wonkwag UH, Iksan, Jeollabukdo, Korea, Republic of
🇰🇷Wonkwang University hospital, Iksan, Korea, Republic of
Comparison of Hemodynamic Stability During Anesthesia Using Remimazolam and Sevoflurane in Minimally Invasive AVR
- Conditions
- Aortic Valve StenosisRemimazolam
- Interventions
- First Posted Date
- 2023-05-18
- Last Posted Date
- 2024-08-12
- Lead Sponsor
- Pusan National University Yangsan Hospital
- Target Recruit Count
- 52
- Registration Number
- NCT05864625
- Locations
- 🇰🇷
Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do, Korea, Republic of
Remimazolam vs Propofol as an Induction Agent for Morbid Obesity Patients
- Conditions
- RemimazolamDesfluraneMorbid ObesitySleeve GastrectomyGeneral Anesthesia
- Interventions
- First Posted Date
- 2023-05-12
- Last Posted Date
- 2023-08-14
- Lead Sponsor
- Seoul National University Bundang Hospital
- Target Recruit Count
- 88
- Registration Number
- NCT05856617
- Locations
- 🇰🇷
Seoul national university Bundang hospital, Seongnam-si, Korea, Republic of
Impact of CES1 Genotype on Remimazolam
- Conditions
- AdultMiddle AgedElective Surgical Procedures
- Interventions
- First Posted Date
- 2023-05-03
- Last Posted Date
- 2024-10-14
- Lead Sponsor
- Korea University Guro Hospital
- Target Recruit Count
- 120
- Registration Number
- NCT05841667
- Locations
- 🇰🇷
Korea University Guro Hospital, Seoul, Korea, Republic of
Remimazolam Versus Midaszolam for Sedation in Diagnostic Upper Gastrointestinal Endoscopy
- First Posted Date
- 2023-05-01
- Last Posted Date
- 2023-05-01
- Lead Sponsor
- Samsung Medical Center
- Target Recruit Count
- 132
- Registration Number
- NCT05836545
- Locations
- 🇰🇷
Samsung Medical Center, Seoul, Korea, Republic of
Drug Development Updates
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