Remimazolam

Generic Name: Remimazolam

Brand Names: Byfavo

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₁₉BrN_₄O_₂

CAS Number: 308242-62-8

Unique Ingredient Identifier: 7V4A8U16MB

Background: Remimazolam is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation during short (<30 minute) procedures. Recent trends in anesthesia-related drug development have touted the benefits of so-called "soft drugs" - these agents, such as remifentanil, are designed to be metabolically fragile and thus susceptible to rapid biotransformation and elimination as inactive metabolites. These "soft drugs" are useful in the context of surgical procedures, wherein a rapid onset/offset is desirable, enabling anesthesiologists to manipulate drug concentrations as needed. Remimazolam was the first "soft" benzodiazepine analog to be developed and was approved for use by the FDA in July 2020 under the brand name Byfavo.

Indication: Remimazolam is indicated for the induction and maintenance of procedural sedation in adults undergoing procedures lasting 30 minutes or less.

Associated Conditions: Procedural Sedation

Clinical Trials

Total Intravenous Anesthesia for Rigid Bronchoscopy Using Remimazolam

Not Applicable

Withdrawn

Conditions: Endobronchial Mass
Respiratory Disease
Tracheal Stenosis

Interventions: Drug: Remimazolam besylate
Drug: Propofol

First Posted Date: 2023-04-28

Last Posted Date: 2025-03-30

Lead Sponsor: Samsung Medical Center

Target Recruit Count: 60

Registration Number: NCT05835713

Continuous Infusion of Remidazolam for Colonoscopic Polypectomy in Elderly Patients

Not Applicable

Completed

Conditions: Colon Disease

Interventions: Drug: Remimazolam
Drug: Propofol

First Posted Date: 2023-04-06

Last Posted Date: 2024-08-13

Lead Sponsor: Tongji Hospital

Target Recruit Count: 114

Registration Number: NCT05801757

Locations: 🇨🇳
Tongji Hospital, Wuhan, Hubei, China

Step 2 of A Two-step Trial to Evaluate the Effectiveness and Safety of Remimazolam Besylate for Sedation in ICU Patients

Phase 3

Completed

Conditions: Mechanical Ventilation
Sedative

Interventions: Drug: Remimazolam besylate
Drug: Propofol
Drug: Remifentanil

First Posted Date: 2023-03-24

Last Posted Date: 2024-01-31

Lead Sponsor: Wuhan Union Hospital, China

Target Recruit Count: 164

Registration Number: NCT05782894

Locations: 🇨🇳
Wuhan Union Hospital, Wuhan, Hubei, China

Comparative Study of Recovery Characteristics Between Remimazolam Anesthesia With Flumazenil and Desflurane Anesthesia for Closed Reduction of Nasal Bone Fracture

Not Applicable

Recruiting

Conditions: Anesthesia

Interventions: Drug: Desflurane
Drug: Remimazolam

First Posted Date: 2023-03-17

Last Posted Date: 2023-09-07

Lead Sponsor: Daegu Catholic University Medical Center

Target Recruit Count: 58

Registration Number: NCT05774366

Locations: 🇰🇷
Daegu Catholic University Medical Center, Daegu, Korea, Republic of

Ideal Dosage for Sedation of Obese Patients Undergoing Knee or Hip Arthroplasty Under Spinal Anesthesia

Phase 4

Not yet recruiting

Conditions: Arthritis Knee
Arthritis Hip

Interventions: Drug: Remimazolam

First Posted Date: 2023-03-08

Last Posted Date: 2023-03-08

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 110

Registration Number: NCT05760534

Effect of Remimazolam on the Recovery Quality After Day Surgery

Not Applicable

Completed

Conditions: Ambulatory Surgery
Elderly Patients

Interventions: Drug: Remimazolam besylate
Drug: etomidate

First Posted Date: 2023-03-01

Last Posted Date: 2024-03-13

Lead Sponsor: Xijing Hospital

Target Recruit Count: 118

Registration Number: NCT05748665

Locations: 🇨🇳
Yan 'an University Affiliated Hospital, Yanan, Shannxi, China
🇨🇳
The Fourth military medical university, Xijing Hospital, Xi'an, Shannxi, China
🇨🇳
Xi 'an International Medical Center Hospital, Xi'an, Shannxi, China

Comparison of Remimazolam and Midazolam for Preventing Intraoperative Nausea and Vomiting During Cesarean Section Under Spinal Anesthesia

Not Applicable

Completed

Conditions: Cesarean Section
Spinal Anesthesia
Pregnancy

Interventions: Drug: Remimazolam besylate
Drug: Midazolam

First Posted Date: 2023-02-21

Last Posted Date: 2024-02-06

Lead Sponsor: Yonsei University

Target Recruit Count: 80

Registration Number: NCT05736341

Locations: 🇰🇷
Yonsei University Health System, Severance Hospital, Seoul, Korea, Republic of

REmimazolam vs Propofol Total Intravenous Anesthesia on Outcomes After Major Noncardiac SurgEry

Phase 4

Recruiting

Conditions: Anesthesia
Surgery-Complications

Interventions: Drug: Remimazolam
Drug: Propofol

First Posted Date: 2023-02-15

Last Posted Date: 2023-04-07

Lead Sponsor: Nanfang Hospital, Southern Medical University

Target Recruit Count: 7188

Registration Number: NCT05728775

Locations: 🇨🇳
Beijing Chaoyang Hospital, Capital Medical University, Beijing, Beijing, China
🇨🇳
Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China
🇨🇳
The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China

and more 14 locations