DeepMed Research

Desflurane

Generic Name: Desflurane

Brand Names: Suprane

Drug Type: Small Molecule

Chemical Formula: C_₃H_₂F_₆O

CAS Number: 57041-67-5

Unique Ingredient Identifier: CRS35BZ94Q

Background: Desflurane, or I-653, a a volatile anesthetic that is more rapidly cleared and less metabolized than previous inhaled anesthetics such as methoxyflurane, sevoflurane, enflurane, or isoflurane.. It was developed in the late 1980s out of a need for a more rapidly acting and rapidly cleared inhaled anesthetic.

Desflurane was granted FDA approval on 18 September 1992.

Indication: Desflurane is indicated for the induction and maintenance of anesthesia in adults, as well as the maintenance of anesthesia in pediatric patients.

Associated Therapies: Induction and Maintenance of General Anesthesia, Maintenance of anesthesia therapy

Clinical Trials

Effect of Volatile- Based Versus Total Intravenous Anesthesia on Brain Homeostasis and Neurocognitive Outcome

Phase 4

Not yet recruiting

Conditions: Brain Edema Caused by Drugs
Cerebral Oxygenation

Interventions: Drug: Sevoflurane
Drug: Desflurane

First Posted Date: 2025-01-17

Last Posted Date: 2025-03-05

Lead Sponsor: Georgia Tsaousi

Target Recruit Count: 84

Registration Number: NCT06779890

Locations: 🇬🇷
AHEPA University Hospital, Thessaloniki, Greece

Desflurane Potentially Induces Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Perioperative Procedures by Modulating Cdc42 and Clock Proteins

Not Applicable

Not yet recruiting

Conditions: Avascular Necrosis of the Femoral Head
Benign Prostatic Hyperplasia (BPH)
Cholecystitis
Knee Osteoarthritis
Coronary Artery Disease (CAD)

Interventions: Drug: Desflurane Inhalation
Device: mechanical ventilation (MV)

First Posted Date: 2025-01-13

Last Posted Date: 2025-01-14

Lead Sponsor: Xiaguang Duan

Target Recruit Count: 60

Registration Number: NCT06772558

Locations: 🇨🇳
Inner Mongolia Baogang Hospital, Baotou, Inner Mongolia, China

Effect of Sevoflurane and Desflurane on Heme Oxygenase-1 Expression in Elective Cholecystectomy

Phase 4

Withdrawn

Conditions: Cholecystitis, Chronic

Interventions: Drug: Sevoflurane Group
Drug: Desflurane Group

First Posted Date: 2024-06-13

Last Posted Date: 2025-02-05

Lead Sponsor: Kocaeli City Hospital

Target Recruit Count: 48

Registration Number: NCT06457958

Locations: 🇹🇷
Kocaeli City Hospital, Kocaeli, Izmit, Turkey

Desflurane Versus Isoflurane for Speeding Postanesthetic Recovery and Hospital Discharge

Not Applicable

Not yet recruiting

Conditions: Surgery

Interventions: Drug: Isoflurane
Drug: Desflurane

First Posted Date: 2024-02-09

Last Posted Date: 2025-02-03

Lead Sponsor: The Cleveland Clinic

Target Recruit Count: 2619

Registration Number: NCT06252207

The Quality of Recovery From General Anesthesia With Desflurane for Fundus Surgery

Early Phase 1

Not yet recruiting

Conditions: Postoperative Recovery
Desflurane Anesthesia

Interventions: Drug: Desflurane Inhalant Product

First Posted Date: 2024-02-05

Last Posted Date: 2024-02-05

Lead Sponsor: Sichuan Provincial People's Hospital

Target Recruit Count: 220

Registration Number: NCT06241131

Impact of Desflurane and Sevoflurane on Postoperative Delirium in Elderly Patients

Not Applicable

Recruiting

Conditions: Postoperative Cognitive Dysfunction
Delirium

Interventions: Drug: Sevoflurane
Drug: Desflurane

First Posted Date: 2023-12-19

Last Posted Date: 2024-06-04

Lead Sponsor: West China Hospital

Target Recruit Count: 890

Registration Number: NCT06176144

Locations: 🇨🇳
Department of Anesthesiology, West China Hospital, Chengdu, Sichuan, China

Desflurane and Sevoflurane on Remifentanil Requirement

Not Applicable

Not yet recruiting

Conditions: Spinal Diseases

Interventions: Drug: Desflurane Inhalation Solution
Drug: Sevoflurane Inhalation Solution

First Posted Date: 2023-11-09

Last Posted Date: 2023-11-09

Lead Sponsor: Ajou University School of Medicine

Target Recruit Count: 78

Registration Number: NCT06123624

The Effect of Anthropometrics on Desflurane Rise Time

Completed

Conditions: Desflurane
Anesthesia, General

Interventions: Drug: Desflurane induction

First Posted Date: 2023-09-06

Last Posted Date: 2023-12-22

Lead Sponsor: Recep Tayyip Erdogan University

Target Recruit Count: 361

Registration Number: NCT06026033

Locations: 🇹🇷
Recep Tayyip Erdogan University Medical Faculty, Department of Anesthesiology and Reanimation, Rize, Turkey

The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium

Phase 4

Recruiting

Conditions: Postoperative Delirium
Postoperative Cognitive Dysfunction
Major Noncardiac Surgery

Interventions: Drug: Desflurane
Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2023-08-14

Last Posted Date: 2025-04-30

Lead Sponsor: Medical University of Vienna

Target Recruit Count: 1332

Registration Number: NCT05990790

Locations: 🇦🇹
Medical University of Innsbruck, Innsbruck, Austria
🇦🇹
Medical University of Vienna, Vienna, Austria

The Effect of Anesthetic Methods on Gastrointestinal Motility

Not Applicable

Completed

Conditions: Anesthesia
Total Intravenous Anesthesia

Interventions: Drug: Remifentanil infusion
Drug: Desflurane
Drug: Propofol infusion
Other: Fresh gas

First Posted Date: 2023-07-19

Last Posted Date: 2024-08-13

Lead Sponsor: Bozyaka Training and Research Hospital

Target Recruit Count: 61

Registration Number: NCT05951686

Locations: 🇹🇷
Izmir Bozyaka Training and Research Hospital, İzmir, Bozyaka, Turkey

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