Desflurane and Sevoflurane on Remifentanil Requirement
Not Applicable
Not yet recruiting
- Conditions
- Spinal Diseases
- Interventions
- Registration Number
- NCT06123624
- Lead Sponsor
- Ajou University School of Medicine
- Brief Summary
The primary purpose of this study is to compare the desflurane and sevoflurane on remifentanil requirement using analgesia nociception index-guided anesthesia in patients undergoing spine surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 78
Inclusion Criteria
- Clinical diagnosis of herniated disc, injury of spinal cord, and neoplasm of spinal meninges
Exclusion Criteria
- Hyperbilirubinemia
- Prior chronic pain
- Prior opioid abuse
- Cardiac arrythmia
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Desflurane group Desflurane Inhalation Solution - Sevoflurane group Sevoflurane Inhalation Solution -
- Primary Outcome Measures
Name Time Method remifentanil requirement at time of the end of skin suture (up to 3 hours) assessing the total dose of remifentanil administered from skin incision until skin suture
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
How do desflurane and sevoflurane modulate the analgesia nociception index (ANI) to influence remifentanil requirements in spinal surgery?
What is the comparative effectiveness of desflurane versus sevoflurane in reducing remifentanil consumption during ANI-guided spinal surgery anesthesia?
Are there specific biomarkers that correlate with differential remifentanil requirements when using desflurane or sevoflurane in ANI-guided anesthesia for spinal diseases?
What adverse events are associated with desflurane and sevoflurane in ANI-guided anesthesia, and how do they compare in terms of safety profiles during spinal surgery?
How do desflurane and sevoflurane compare to other inhalational anesthetics in ANI-guided remifentanil-sparing strategies for spinal surgery patients?