Comparison of the Effects of Sevoflurane and Desflurane on Prevention of Catheter-related Bladder Discomfort
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 108
- 试验地点
- 1
- 主要终点
- Catheter-related bladder discomfort
研究概览
简要总结
We want to evaluate the efficacy of the sevoflurane and desflurane for the prevention of catheter-related bladder discomfort.
详细描述
The mechanism of catheter-related bladder discomfort is thought to be related to the muscarinic receptor. The volatile anesthetics such as sevoflurane and desflurane are known to block the muscarinic receptor in different ways.
We want to evaluate the efficacy of the sevoflurane and desflurane for the prevention of catheter-related bladder discomfort.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients scheduled for transurethral bladder excision under general anesthesia
- •ASA I-III
排除标准
- •Bladder outflow obstruction
- •Overactive bladder
- •End-stage renal disease
- •Neurogenic bladder
- •Heart failure
- •Arrhythmia
- •Morbid obesity
- •Use of chronic analgesic medication
- •Hepatic disease
- •Pulmonary disease
- •Psychiatric disease
研究组 & 干预措施
Sevoflurane
Sevoflurane will be administered as the maintenance agent of general anesthesia.
干预措施: Sevoflurane (Drug)
Desflurane
Desflurane will be administered as the maintenance agent of general anesthesia.
干预措施: Desflurane (Drug)
结局指标
主要结局
Catheter-related bladder discomfort
时间窗: 24 hour postoperatively
Catheter-related bladder discomfort will be measured for 24 hour postoperatively (0:none, 1:mild, 2:moderate, 3:severe).
次要结局
- Vomiting(0, 1, 6 and 24 hour postoperatively)
- Dry mouth(0 houe after admission of operating room)
- Catheter-related bladder discomfort(0, 1, 6 and 24 hour postoperatively)
- Nausea(0, 1, 6 and 24 hour postoperatively)