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临床试验/NCT01486953
NCT01486953Unknown4 期

Phase 4 Study of Desflurane and Sevoflurane That Affect Pulmonary Mechanics During Minimally Invasive Repair of Pectus Excavatum

The Catholic University of Korea1 个研究点 分布在 1 个国家目标入组 70 人开始时间: 2011年11月最近更新:
适应症
干预措施
相关药物

试验速览

阶段
4 期
入组人数
70
试验地点
1
主要终点
pulmonary mechanics

研究概览

简要总结

The aim of the current study was to compare the effects of sevoflurane and desflurane on respiratory mechanics in patients undergoing repair of pectus excavatum.

详细描述

The minimally invasive technique for pectus excavatum repair was introduced by Nuss and colleagues using a metal bar to lift the depressed chest wall. This surgical procedure is usually done under general anesthesia with tracheal intubation. After inserting metal bar into the chest wall, decreased lung compliance was shown. Previous studies demonstrated that administering desflurane during anesthesia resulted in marked increases in respiratory mechanical parameters, especially in the children with airway susceptibility. Our primary hypothesis was that desflurane would cause an increase in respiratory resistance and a decrease in lung compliance compared to sevoflurane during repair of pectus excavatum.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Supportive Care
盲法
Single (Participant)

入排标准

年龄范围
15 Years 至 —(Child, Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • clinical diagnosis of Pectus Excavatum
  • undergoing minimally invasive repair

排除标准

  • younger than 15 year old
  • history of upper respiratory tract infection within recent 2 weeks
  • chronic obstructive pulmonary disease
  • previous treatment with bronchoactive drugs (B-agonist or antagonist, theophyline, anticholinergics and corticosteroid)
  • history of neurological deficits

研究组 & 干预措施

sevoflurane

Active Comparator

Anesthesia with sevoflurane

干预措施: Sevoflurane (Drug)

Desflurane

Experimental

Anesthesia with desflurane

干预措施: Desflurane (Drug)

结局指标

主要结局

pulmonary mechanics

时间窗: within the 2 hours during the surgery

respiratory resistance dynamic and static lung compliance

次要结局

  • complication(within 72 hours after sugery)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Jeong Eun Kim

Clinical Assistant Professor

The Catholic University of Korea

研究点 (1)

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