Pulmonary Mechanics During Minimally Invasive Repair of Pectus Excavatum

Phase 4

• Conditions: Pectus Excavatum
• Interventions: Drug: Desflurane; Drug: Sevoflurane

• Registration Number: NCT01486953
• Lead Sponsor: The Catholic University of Korea

Brief Summary

The aim of the current study was to compare the effects of sevoflurane and desflurane on respiratory mechanics in patients undergoing repair of pectus excavatum.

Detailed Description

The minimally invasive technique for pectus excavatum repair was introduced by Nuss and colleagues using a metal bar to lift the depressed chest wall. This surgical procedure is usually done under general anesthesia with tracheal intubation. After inserting metal bar into the chest wall, decreased lung compliance was shown. Previous studies demonstrated that administering desflurane during anesthesia resulted in marked increases in respiratory mechanical parameters, especially in the children with airway susceptibility. Our primary hypothesis was that desflurane would cause an increase in respiratory resistance and a decrease in lung compliance compared to sevoflurane during repair of pectus excavatum.

Study Timeline

• Study Start: 2011-11
• Study First Submitted: 2011-11-26
• Study First Submitted QC: 2011-12-05
• Study First Posted: 2011-12-07
• Status Verified: 2013-07
• Last Update Submitted: 2013-07-22
• Last Update Posted: 2013-07-23
• Primary Completion: 2014-04
• Study Completion: 2014-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• clinical diagnosis of Pectus Excavatum
• undergoing minimally invasive repair

Exclusion Criteria

• younger than 15 year old
• history of upper respiratory tract infection within recent 2 weeks
• asthma
• chronic obstructive pulmonary disease
• previous treatment with bronchoactive drugs (B-agonist or antagonist, theophyline, anticholinergics and corticosteroid)
• history of neurological deficits

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Desflurane	Desflurane	Anesthesia with desflurane
sevoflurane	Sevoflurane	Anesthesia with sevoflurane

Primary Outcome Measures

Name	Time	Method
pulmonary mechanics	within the 2 hours during the surgery	respiratory resistance dynamic and static lung compliance

Secondary Outcome Measures

Name	Time	Method
complication	within 72 hours after sugery	bronchospasm dyspnea pneumothorax

Trial Locations

Locations (1)

Seoul St. Mary's Hospital; 🇰🇷 Seoul, Korea, Republic of