Phase 4 Study of Desflurane and Sevoflurane That Affect Pulmonary Mechanics During Minimally Invasive Repair of Pectus Excavatum
Overview
- Phase
- Phase 4
- Intervention
- Sevoflurane
- Conditions
- Pectus Excavatum
- Sponsor
- The Catholic University of Korea
- Enrollment
- 70
- Locations
- 1
- Primary Endpoint
- pulmonary mechanics
- Last Updated
- 12 years ago
Overview
Brief Summary
The aim of the current study was to compare the effects of sevoflurane and desflurane on respiratory mechanics in patients undergoing repair of pectus excavatum.
Detailed Description
The minimally invasive technique for pectus excavatum repair was introduced by Nuss and colleagues using a metal bar to lift the depressed chest wall. This surgical procedure is usually done under general anesthesia with tracheal intubation. After inserting metal bar into the chest wall, decreased lung compliance was shown. Previous studies demonstrated that administering desflurane during anesthesia resulted in marked increases in respiratory mechanical parameters, especially in the children with airway susceptibility. Our primary hypothesis was that desflurane would cause an increase in respiratory resistance and a decrease in lung compliance compared to sevoflurane during repair of pectus excavatum.
Investigators
Jeong Eun Kim
Clinical Assistant Professor
The Catholic University of Korea
Eligibility Criteria
Inclusion Criteria
- •clinical diagnosis of Pectus Excavatum
- •undergoing minimally invasive repair
Exclusion Criteria
- •younger than 15 year old
- •history of upper respiratory tract infection within recent 2 weeks
- •chronic obstructive pulmonary disease
- •previous treatment with bronchoactive drugs (B-agonist or antagonist, theophyline, anticholinergics and corticosteroid)
- •history of neurological deficits
Arms & Interventions
sevoflurane
Anesthesia with sevoflurane
Intervention: Sevoflurane
Desflurane
Anesthesia with desflurane
Intervention: Desflurane
Outcomes
Primary Outcomes
pulmonary mechanics
Time Frame: within the 2 hours during the surgery
respiratory resistance dynamic and static lung compliance
Secondary Outcomes
- complication(within 72 hours after sugery)