An Observational Study on the Effect of Sevoflurane on Airway Hyperreactivity in Children with RSV Infection During the Perioperative Period.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 97
- 试验地点
- 2
- 主要终点
- Intraoperative ventilator parameters
研究概览
简要总结
To investigate the effects of sevoflurane on respiratory parameters and respiratory inflammation in healthy and RSV-infected under general anesthesia and to propose suitable perioperative airway protection measures for children with respiratory virus infection undergoing general anesthesia.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 2 Years 至 5 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients voluntarily joined this study and signed an informed consent form；
- •Age: 2-5 years old；
- •The patient should have a good general condition and no serious internal medicine comorbidities (ASA classification of the American Anesthesiology Association is Grade I); BMI ≤ 20;
- •Plan to undergo elective adenoidectomy or adenotonsillectomy with tracheal intubation.
排除标准
- •Children with a history of allergic asthma;
- •Children with space-occupying lesions of the chest and lungs, or acute bronchiolitis or pneumonia;
- •Children with cardiovascular diseases that may cause cough, wheezing, and other symptoms;
- •Children who used leukotriene modulators, β2 receptor agonists, anticholinergics, theophyllines, or hormonal treatment drugs within two weeks;
- •Children allergic to propofol, sevoflurane, or other anesthetic agents;
- •Children with a family history of malignant hyperthermia;
- •Children with liver and kidney dysfunction;
- •The result of rapid antigen detection and nucleic acid test for RSV was inconsistent, or children combined with pathogen infections other than RSV;
- •Children with fever.
研究组 & 干预措施
Control group
The nasopharyngeal swab test for RSV antigen was negative for patients with no history of respiratory infection in the past six weeks before surgery.
干预措施: Sevoflurane (Volatile Anesthetic) (Drug)
Control group
The nasopharyngeal swab test for RSV antigen was negative for patients with no history of respiratory infection in the past six weeks before surgery.
干预措施: propofol (Drug)
RSV group
The nasopharyngeal swab of the RSV antigen test is positive.
干预措施: Sevoflurane (Volatile Anesthetic) (Drug)
RSV group
The nasopharyngeal swab of the RSV antigen test is positive.
干预措施: propofol (Drug)
结局指标
主要结局
Intraoperative ventilator parameters
时间窗: After induction of general anesthesia and intubation; at the end of anesthesia
Airway pressure(including Paw, PIP, Pplat), and pulmonary compliance.
次要结局
- Inflammation response indications(After induction of general anesthesia and intubation; at the end of anesthesia)
研究者
Liu Weiwei
associate professor of anesthesiology department
First Hospital of China Medical University