Remimazolam
- Generic Name
- Remimazolam
- Brand Names
- Byfavo
- Drug Type
- Small Molecule
- Chemical Formula
- C21H19BrN4O2
- CAS Number
- 308242-62-8
- Unique Ingredient Identifier
- 7V4A8U16MB
- Background
Remimazolam is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation during short (<30 minute) procedures. Recent trends in anesthesia-related drug development have touted the benefits of so-called "soft drugs" - these agents, such as remifentanil, are designed to be metabolically fragile and thus susceptible to rapid biotransformation and elimination as inactive metabolites. These "soft drugs" are useful in the context of surgical procedures, wherein a rapid onset/offset is desirable, enabling anesthesiologists to manipulate drug concentrations as needed. Remimazolam was the first "soft" benzodiazepine analog to be developed and was approved for use by the FDA in July 2020 under the brand name Byfavo.
- Indication
Remimazolam is indicated for the induction and maintenance of procedural sedation in adults undergoing procedures lasting 30 minutes or less.
- Associated Conditions
- Procedural Sedation
A Non-intervention Fiberoptic Bronchoscopy Study of Remazolam Toluene Sulfonate for Injection Under General Anesthesia and Fiberoptic Bronchoscopy
- Conditions
- General Anesthesia and Bronchoscopy Sedation
- Interventions
- First Posted Date
- 2022-09-22
- Last Posted Date
- 2022-09-22
- Lead Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
- Target Recruit Count
- 1000
- Registration Number
- NCT05549791
Hypotension After Anesthetic Induction With Remimazolam in Elderly
- Conditions
- Hypotension
- Interventions
- Drug: Continuous infusion of remimazolam
- First Posted Date
- 2022-09-14
- Last Posted Date
- 2023-06-02
- Lead Sponsor
- Kangbuk Samsung Hospital
- Target Recruit Count
- 66
- Registration Number
- NCT05538741
- Locations
- 🇰🇷
Kangbuk Samsung Hospital, Seoul, Korea, Republic of
Efficacy and Safety of Remimazolam Besylate Versus Propofol for Sedation in Critically Ill Patients With Deep Sedation
- Conditions
- Critically IllDeep Sedation
- Interventions
- First Posted Date
- 2022-09-14
- Last Posted Date
- 2022-09-26
- Lead Sponsor
- Wuhan Union Hospital, China
- Target Recruit Count
- 60
- Registration Number
- NCT05539521
- Locations
- 🇨🇳
Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Bolus Versus Continuous Remimazolam for Anesthetic Induction
- Conditions
- Hypotension on Induction
- Interventions
- First Posted Date
- 2022-09-10
- Last Posted Date
- 2023-06-02
- Lead Sponsor
- Kangbuk Samsung Hospital
- Target Recruit Count
- 62
- Registration Number
- NCT05536323
Electroencephalographic Profiles During General Anesthesia: a Comparative Study of Remimazolam and Propofol
- Conditions
- General AnesthesiaRemimazolamPropofolLaparoscopic CholecystectomyElectroencephalography
- Interventions
- First Posted Date
- 2022-09-09
- Last Posted Date
- 2022-09-29
- Lead Sponsor
- Second Affiliated Hospital of Nanchang University
- Target Recruit Count
- 12
- Registration Number
- NCT05533567
- Locations
- 🇨🇳
the Second Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, Jiangxi, China
Differential Effects of Remimazolam and Propofol on Dynamic Cerebral Autoregulation During General Anesthesia
- Conditions
- General AnesthesiaLaparoscopic CholecystectomyRemimazolamPropofolDynamic Cerebral Autoregulation
- Interventions
- First Posted Date
- 2022-09-09
- Last Posted Date
- 2022-09-29
- Lead Sponsor
- Second Affiliated Hospital of Nanchang University
- Target Recruit Count
- 50
- Registration Number
- NCT05533580
- Locations
- 🇨🇳
the Second Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, Jiangxi, China
Effect of Remimazolam vs Sevoflurane Anesthesia on Incidence of Emergence Agitation and Complications in Children Undergoing Ophthalmic Surgery
- Conditions
- RemimazolamSevofluranePediatric Ophthalmic SurgeryEmergence AgitationAnesthesia, General
- Interventions
- First Posted Date
- 2022-09-02
- Last Posted Date
- 2023-03-24
- Lead Sponsor
- Second Affiliated Hospital of Nanchang University
- Target Recruit Count
- 110
- Registration Number
- NCT05527314
- Locations
- 🇨🇳
the Second Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, Jiangxi, China
Comparison of the Effect of Remimazolam With Sevoflurane on Postanesthetic Shivering
- First Posted Date
- 2022-08-31
- Last Posted Date
- 2022-08-31
- Lead Sponsor
- Wonkwang University Hospital
- Target Recruit Count
- 74
- Registration Number
- NCT05523037
- Locations
- 🇰🇷
Wonkwag UH, Iksan, Jeollabukdo, Korea, Republic of
Remimazolam and Scoliosis Orthopedics
- First Posted Date
- 2022-08-29
- Last Posted Date
- 2022-08-29
- Lead Sponsor
- Beijing Chao Yang Hospital
- Target Recruit Count
- 148
- Registration Number
- NCT05519371
Effect of Remimazolam and Propofol on Postoperative Delirium
- Conditions
- Knee OsteoarthritisHip FracturesFemur Fracture
- Interventions
- First Posted Date
- 2022-08-24
- Last Posted Date
- 2024-03-08
- Lead Sponsor
- Inje University
- Target Recruit Count
- 82
- Registration Number
- NCT05514405
- Locations
- 🇰🇷
Sanggye Paik hospital, Seoul, Korea, Republic of
Drug Development Updates
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