Comparison of the Incidence of Hypotension With Bolus Versus Continuous Remimazolam for Anesthetic Induction in Elderly Patients
Overview
- Phase
- Not Applicable
- Intervention
- Bolus of remimazolam
- Conditions
- Hypotension
- Sponsor
- Kangbuk Samsung Hospital
- Enrollment
- 66
- Locations
- 1
- Primary Endpoint
- The incidence of hypotension
- Status
- Not yet recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Even though remimazolam is known to be safely administered without hemodynamic instability, hypotension is the one of the common side effects of remimazolam. Because elderly patients are susceptible to hypotension due to old age, multimodality, and multiple medications, hypotension can be harmful in elderly patients. Remimazolam can be administered either bolus or continuous for anesthetic induction. In our study the investigators aimed to compare the incidence of hypotension after anesthetic induction using remimazolam by bolus injection and continuous infusion in elderly patients.
Investigators
Eunah Cho, MD
Assistant Professor
Kangbuk Samsung Hospital
Eligibility Criteria
Inclusion Criteria
- •Elderly patients with age over 60 years old
- •scheduled for elective surgery under general anesthesia
- •American Society of Anesthesiology Physical Status I-III
Exclusion Criteria
- •Arrhythmia
- •Liver dysfunction
- •Kidney dysfunction
- •Uncontrolled hypertension
- •Uncontrolled diabetes mellitus
- •Allergic to benzodiazepines
- •Heart failure
- •Drug intoxication
- •Alcoholics
- •Cognitive dysfunction
Arms & Interventions
Bolus
Remimazolam bolus injection for 20 seconds
Intervention: Bolus of remimazolam
Continuous
Remimazolam continuous infusion
Intervention: Continuous infusion of remimazolam
Outcomes
Primary Outcomes
The incidence of hypotension
Time Frame: 10 minutes after intubation
Systolic blood pressure \< 90 mmHg
Secondary Outcomes
- The incidence of bradycardia(10 minutes after intubation)
- Number of participants with use of any vasopressors(10 minutes after intubation)
- Lowest systolic blood pressure(10 minutes after intubation)
- Time to loss of consciousness(10 minutes after intubation)
- Total remimazolam used for anesthetic induction(10 minutes after intubation)