The Comparison of Hypotension Incidence Between Remimazolam and Propofol in Hypertensive Patients Undergoing Neurosurgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- incidence of hypotension events
研究概览
简要总结
This study aims to find an excellent drug in terms of hemodynamic stability when comparing the propofol and remifentanil with the combined use of remimazolam and remifentanil. When the mean blood pressure falls by 20% or more from the baseline mean blood pressure, it is considered hypotension, and a vasopressor such as ephedrine, phenylephrine, or norpin is used to control the blood pressure to within 20% of the baseline blood pressure. If the blood pressure increases by 20% or more above the baseline mean blood pressure, nicardipine infusion or remimazolam, propofol or remifentanil should be increased to control the blood pressure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 19 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •hypertension
- •patients undergoing neurosurgery
- •19-75 year-old patients
排除标准
- •Patients admitted on the day of surgery
- •cardiac disease
- •liver failure or liver cirrhosis
- •increased intracranial pressure(IICP)
- •mental change
研究组 & 干预措施
propofol group
During the induction, propofol was controlled according to sedline (Psi target 40)
干预措施: propofol (Drug)
remimazolam group
During induction, remimazolam dose was controlled according to sedline (Psi target 40)
干预措施: remimazolam (Drug)
结局指标
主要结局
incidence of hypotension events
时间窗: procedure (during induction before the surgery)
Hypotension is considered when the mean blood pressure is 20% or more below the baseline mean blood pressure.
次要结局
- blood pressure(procedure (during induction before the surgery))
- heart rate(procedure (during induction before the surgery))
- sedline psi(procedure (during induction before the surgery))