The Comparison of Hypotension Incidence Between Remimazolam and Propofol in Hypertensive Patients Undergoing Neurosurgery
Overview
- Phase
- Not Applicable
- Intervention
- propofol
- Conditions
- Patients Undergoing Neurosurgery
- Sponsor
- Yonsei University
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- incidence of hypotension events
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
This study aims to find an excellent drug in terms of hemodynamic stability when comparing the propofol and remifentanil with the combined use of remimazolam and remifentanil. When the mean blood pressure falls by 20% or more from the baseline mean blood pressure, it is considered hypotension, and a vasopressor such as ephedrine, phenylephrine, or norpin is used to control the blood pressure to within 20% of the baseline blood pressure. If the blood pressure increases by 20% or more above the baseline mean blood pressure, nicardipine infusion or remimazolam, propofol or remifentanil should be increased to control the blood pressure.
Investigators
Eligibility Criteria
Inclusion Criteria
- •hypertension
- •patients undergoing neurosurgery
- •19-75 year-old patients
Exclusion Criteria
- •Patients admitted on the day of surgery
- •cardiac disease
- •liver failure or liver cirrhosis
- •increased intracranial pressure(IICP)
- •mental change
Arms & Interventions
propofol group
During the induction, propofol was controlled according to sedline (Psi target 40)
Intervention: propofol
remimazolam group
During induction, remimazolam dose was controlled according to sedline (Psi target 40)
Intervention: remimazolam
Outcomes
Primary Outcomes
incidence of hypotension events
Time Frame: procedure (during induction before the surgery)
Hypotension is considered when the mean blood pressure is 20% or more below the baseline mean blood pressure.
Secondary Outcomes
- blood pressure(procedure (during induction before the surgery))
- heart rate(procedure (during induction before the surgery))
- sedline psi(procedure (during induction before the surgery))